OPTIMASI SEDIAAN SUNSCREEN SPRAY GEL EKSTRAK ETANOL TONGKOL JAGUNG (ZEA MAYS L.) DAN ZINK OKSIDA DENGAN VARIASI BASIS HPMC-KARBOPOL940

SHAFIRA, INTAN and Shiyan, Shaum and Apriani, Elsa Fitria (2022) OPTIMASI SEDIAAN SUNSCREEN SPRAY GEL EKSTRAK ETANOL TONGKOL JAGUNG (ZEA MAYS L.) DAN ZINK OKSIDA DENGAN VARIASI BASIS HPMC-KARBOPOL940. Undergraduate thesis, Sriwijaya University.

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Abstract

Excessive sun exposure can cause damage to the skin due to ultraviolet (UV) radiation so that the skin needs additional protection to avoid UV radiation. Sunscreen products can reduce the transmission of UV rays to the skin. Zinc oxide is one of the active ingredients that works as a physical blocker that is widely used, but has very low solubility and stability so that it is formulated in the form of emulsions with the aim of increasing its solubility. Corncob extract has potential as an antioxidant, namely phenolic which is also in line with the value of Sun Protection Factor (SPF). This study aims to determine the physical properties and SPF value of the optimum formula of the preparation of sunscreen spray gel corncob extract. Corn cobs were extracted by maceration method and yield a yield of 15.28%. Corncob extract was tested for total phenolics and determined the SPF value so that the total phenolic value of 13 mg GAE / g sample was tested and the SPF value at a concentration of 1000 ppm was 20,351 with moderate UV protection category. Corn cob extract was formulated into a spray gel dosage form with variations on the basis of HPMC-Karbopol940. Both bases were optimized using a design expert with a 3 replication factorial design approach which resulted in 12 run formulas. The responses analyzed were adhesive dispersion, drying power, viscosity and SPF value. The test results were analyzed by DX12 to get the optimum formula. The optimum concentration of HPMC was 0.171 % and carbopol940 0.300 % with adhesive dispersion of 138.8 seconds, drying power of 153.6 seconds, viscosity of 409 cPs and SPF value of 13.095 with moderate protection category.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	tongkol jagung, optimasi, sunscreen, spray gel, SPF
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Intan Shafira
Date Deposited:	15 Aug 2022 01:52
Last Modified:	15 Aug 2022 01:52
URI:	http://repository.unsri.ac.id/id/eprint/77194

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