IDENTIFIKASI POLIMORFISME GEN CYP2A6 PADA PENDERITA KARSINOMA NASOFARING DI RUMAH SAKIT DR.MOHAMMAD HOESIN PALEMBANG

HADI, ABDURRAHMAN and Hayati, Lusia and Saleh, Saleh (2013) IDENTIFIKASI POLIMORFISME GEN CYP2A6 PADA PENDERITA KARSINOMA NASOFARING DI RUMAH SAKIT DR.MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Karsinoma Nasofaring (KNF) merupakan suatu keganasan yang berasal dari sel epitel nasofaring. Penderita KNF jarang ditemukan di negara- negara Barat, namun prevalensinya ditemukan cukup tinggi di Cina Selatan dan Asia Tenggara. Di Indonesia, berdasarkan data laboratorium patologi anatomi, KNF selalu berada dalam kedudukan lima besar dari tumor ganas tubuh. Nitrosamin saat ini telah teridentifikasi menjadi zat kasinogenik yang memicu KNF. Pada penelitian ini, diidentifikasi gen yang memetabolisme nitrosamin, sitokrom P450 2A6 (CYP2A6), mempunyai peran penting dalam perkembangan KNF. Metode: Penelitian ini beijenis deskriptif dengan pendekatan cross sectional yang dilakukan kepada 47 partisipan penderita KNF. Identifikasi polimorfisme CYP2A6 dilakukan dengan teknik PCR (Polymerase Chain Reaction) amplifikasi dan RFLP (Restriction Fragment Length Polymorphism) menggunakan enzim BstUl untuk mendeteksi alel wild type dan mutan yaitu *1A dan non*lA. Hasil: Distribusi frekuensi genotip CYP2A6*1A/*1A, *!A/non*lA, dan non*lA/non*lA gen CYP2A6 pada subyek masing-masing 7 orang (14,89%), 27 orang (57,45%), dan 13 orang (27,66%). Distribusi frekuensi alel CYP2A6 untuk alel adalah *1A 41alel (43,62%) dan alel non*lA adalah 53 alel (56,38%). Kesimpulan: ditemukan tingginya frekuensi alel mutan non*JA gen CYP2A6 (56,38%) pada pasien karsinoma nasofaring.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Karsinoma Nasofaring, Polimorfisme, Gen CYP2A6, Nitrosamin
Subjects:	R Medicine > RF Otorhinolaryngology > RF341-437 Rhinology. Diseases of the nose, accessory sinuses, and nasopharynx
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Beta Ria Febrianti
Date Deposited:	13 Oct 2022 03:22
Last Modified:	13 Oct 2022 03:22
URI:	http://repository.unsri.ac.id/id/eprint/80707

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