IDENTIFIKASI POLIMORFISME PROGINS (INSERSI ALU 306-PB) GEN RESEPTOR PROGESTERON PADA PENDERITA ENDOMETRIOSIS DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG

SHAFFRIAL, MUHAMMAD NUR and Saleh, Mgs. Irsan and Subandrate, Subandrate (2014) IDENTIFIKASI POLIMORFISME PROGINS (INSERSI ALU 306-PB) GEN RESEPTOR PROGESTERON PADA PENDERITA ENDOMETRIOSIS DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Introduction: Endometriosis, a disease defined as the growth of endometrial tissue with glands and/or stroma outside the uterine cavity, generally occurs in reproductive-age women. Although the etiology still remain unclear, heredity and genetic mutations may contribute in the occurrence of endometriosis. One of the genetic mutations, i.e. PROGINS (306-bp Alu insertion) polymorphism. This polymorphism inhibits the activity of PR-B, therefore increasing the PR-A/PR-B and trigger endometriosis. This study is conducted to identify PROGINS (306-bp Alu insertion) progesterone receptor gene polymorphism in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Method: This study is an observational descriptive study on 48 endometriosis patients in Dr. Mohammad Hoesin General Hospital Palembang. Polymerase Chain Reaction (PCR) was performed to identify. Results: Tl/Tl (wild type) genotype was identified in 43 patients (89,6%) and T1/T2 (heterozygous mutant) genotype in five patients (10.4%). Out of 48 patients, T1 (wild type) allotype frequency was 91 (94.8%) and T2 (polymorphic) allotype was five (5.2%). Conclusion: Genotype Tl/Tl (wild type) and allotype T1 (wild type) were more commonly identified in this study.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	endometriosis, polymorphism, progesterone receptor gene, PROGINS, 306-bp Alu insertion
Subjects:	R Medicine > RC Internal medicine > RC648-665 Diseases of the endocrine glands. Clinical endocrinology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	18 Nov 2022 02:53
Last Modified:	18 Nov 2022 02:53
URI:	http://repository.unsri.ac.id/id/eprint/81876

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