IDENTIFIKASI POLIMORFISME-938C>A PROMOTER GEN BCL-2 PADA PENDERITA KARSINOMA OVARIUM EPITEL DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG

SUSILOWATI, RETNO and Saleh, Mgs. Irsan and Subandrate, Subandrate (2014) IDENTIFIKASI POLIMORFISME-938C>A PROMOTER GEN BCL-2 PADA PENDERITA KARSINOMA OVARIUM EPITEL DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Epithelial ovarian carcinoma is a malignancy arising from ovarian epithelial cell. The cellular transformation into malignant cell is known to be influenced by Bcl-2 protein family which acts as antiapoptotic agent. The -938C>A polymorphism on the Bcl-2 gene is known to be associated with various types of carcinoma. Hence, this study was proposed to identify the -938C>A polymorphism on Bcl-2 gene of epithelial ovarian carcinoma patients at dr. Mohammad Hoesin Hospital Palembang. Methods: This study was an observational descriptive study on 40 epithelial ovarian carcinoma patients at dr. Mohammad Hoesin Hospital Palembang. Identification of the -938C>A polymorphism on Bcl-2 gene was done by PCRRFLP using Bccl enzyme. Result: Zero subject (0%) with CC genotype (wild type) was identified. 17 subjects (42,5%) were in CA genotype (heterozigous mutant) and 23 subjects (57,5%) were in AA genotype (homozigous mutant). From 40 subjects in this study, 17 C allotype (21,25%) and 63 A allotype (78,75%) were identified. Conclusion: The frequencies of AA genotype and A allotype was found higher in epithelial ovarian carcinoma at RSMH Palembang.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	carcinoma, ovarian, polymorphism, -938C>A, Bcl-2
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	15 Nov 2022 07:54
Last Modified:	15 Nov 2022 07:54
URI:	http://repository.unsri.ac.id/id/eprint/81883

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