IDENTIFIKASI POLIMORFISME +331G/A GEN RESEPTOR PROGESTERON PADA PENDERITA ENDOMETRIOSIS DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

NAWAWI, RIZKI ANDINI and Saleh, Mgs. Irsan and Subandrate, Subandrate (2014) IDENTIFIKASI POLIMORFISME +331G/A GEN RESEPTOR PROGESTERON PADA PENDERITA ENDOMETRIOSIS DI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Introduction: Endometriosis is a benign gynecologic disorder often occurring in reproductive-age women marked by the presence of endometrial glands and stromal cells outside the uterine cavity. The etiology of endometriosis remains unclear until now, but genetic factors possibly contribute in the pathogenesis of endometriosis. One of the genetic factors thought to be influencing the occurrence of endometriosis is the +331 G/A progesterone receptor gene polymorphism. This polymorphism causes an increase in the synthesis of PR-B receptor isoform, therefore reducing the PR-A/PR-B isoform ratio and increasing endometriosis risk This study aims to identify +331 G/A progesterone receptor gene polymorphism in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Method: This study is an observational descriptive study on 48 endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Identification of +331 G/A progesterone receptor gene polymorphism was performed through polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP) using NlalV restriction enzyme. Results: The GG (wild type) genotype was identified in 19 patients (39,6%) and the G A (heterozygous mutant) genotype in 29 patients (60,4%). The allotype frequencies for the G (wild type) and A (polymorphic) allotype s were 67 (69,8%) and 29 (30,2%), respectively. Conclusion: In endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, the genotype G A was more commonly identified and the A allotype frequency was 30,2%.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	endometriosis, polymorphism, progesterone receptor gene, +331 G/A
Subjects:	R Medicine > RG Gynecology and obstetrics > RG211-483 Abnormalities and diseases of the female genital organs
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	24 Nov 2022 05:57
Last Modified:	24 Nov 2022 05:57
URI:	http://repository.unsri.ac.id/id/eprint/82480

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