EFEKTIVITAS EKSTRAK ETANOL DAUN KETEPENG CINA (Senna alata L.)SEBAGAI ANTIDIABETES TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN

ANGGRAINI, PUTRI DAMAYANTI and Herlina, Herlina and Solihah, Indah (2018) EFEKTIVITAS EKSTRAK ETANOL DAUN KETEPENG CINA (Senna alata L.)SEBAGAI ANTIDIABETES TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN. Undergraduate thesis, Sriwijaya University.

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Abstract

Antidiabetic activity test of ethanolic extract Seven golden candlestik’s leaves (Senna alata L.) to rats induced by alloxan has been done. Male wistar albino rats were used as animal models which divided into 6 groups, normal group (aquadest), negative control group (Sodium CMC 0,5%), positive control group (insulin by 1IU/kgBW), and 3 test group (ethanolic extract of seven golden candlestik’s leaves 200, 400, dan 800 mg/kgBW). Rats blood glucose level after induced intraperitoneally by alloxan 130 mg/kgBW can be stated as diabetic when >200 mg/dL. Antidiabetic-activity was tested by measuring on blood sugar levels by using the DTN-410-K fotometer, on day 0, 5, 10, and 15. The result of AUC0-15 and percentage of decreasing blood sugar levels for positive control group are 2557.35 and 51.20%, and 3 treatment groups (200, 400, and 800 mg/kgBW) 2745.6 and 39.94%; 2618.55 and 47.54%; 2448.425 and 57.72%.This point indicated that the ethanolic extract of seven golden candlestik’s leaves has an antidiabetic activity and there is no significant difference compared with insulin (p<0,05). Effectivity of 800 mg/kgBW dose from other treatment doses, because it had the lowest AUC0-15 and the highest perscentage of decreasing blood sugar levels. According to the relation between percentage of blood glucose decrease level with dose, value of ED50 of ethanolic extract of seven golden candlestik’s leaves is 522.413 mg/kgBW.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: ethanolic extract, Seven golden candlestik’s leaves, antidiabetic, alloxan, insulin
Subjects: Q Science > QK Botany > QK1-989 Botany
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 25 Jul 2019 08:47
Last Modified: 25 Jul 2019 08:47
URI: http://repository.unsri.ac.id/id/eprint/833

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