EFEK ANTIJAMUR EKSTRAK ETIL ASETAT DAN EKSTRAK METANOL DAUN KAMBOJA MERAH (Plumeria rubra L.) TERHADAP Candida albicans SECARA in vitro

PUTRA, FAHRIZAL DWIANO and Hariyadi, Kusumo and Nita, Sri (2012) EFEK ANTIJAMUR EKSTRAK ETIL ASETAT DAN EKSTRAK METANOL DAUN KAMBOJA MERAH (Plumeria rubra L.) TERHADAP Candida albicans SECARA in vitro. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04081001091.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (63MB) | Request a copy
Preview	Text RAMA_11201_04081001091_9990039025_9990536994_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (17MB) | Preview
	Text RAMA_11201_04081001091_9990039025_9990536994_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (12MB) | Request a copy
	Text RAMA_11201_04081001091_9990039025_9990536994_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (7MB) | Request a copy
	Text RAMA_11201_04081001091_9990039025_9990536994_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (9MB) | Request a copy
	Text RAMA_11201_04081001091_9990039025_9990536994_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (835kB) | Request a copy
	Text RAMA_11201_04081001091_9990039025_9990536994_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_11201_04081001091_9990039025_9990536994_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (14MB) | Request a copy

Abstract

Background: This research was conducted to know whether Plumeria rubra leaves extract has antifungal activity against Candida albicans causing candidiasis; to know wich extract has better effect against Candida albicans growth; and to assess The Minimum lnhibitory Concentration (MIC). Methods: This research was designed as laboratory experimental, using Posttest Only Control group design. Plumeria leaves extract was obtained by multilevel maceration method using two solvents, consist aethyl acetat, and methanol. Then, extract was tested to perform antifungal activity against Candida albicans using Kirby-Bauer Disc Method and then the result was statistically analyzed by SPSS version 18 for Windows. Results: Both of Plumeria rubra leaves extract from aethylacetat and methanol solvents can inhibit the Candida albicans growth in the Sabouroud Dextrose Agar medium. And both of them have the same effectiveness in term of antifungal activity in inhibiting the Candida albicans growth. The minimum inhibitory concentration (MIC) for aetil acetat extract is 0,02 gr/ml; and for methanol extract is 0,03 gr/ml. The concentration of aetyl acetat extract has an average level of correlation to the inhibitory zone diameter according to its Pearson correlation value (r = 0,394); but this correlation is not significant based on its significant value (p = 0,131) while the concentration of methanol extract has a strong level of correlation to the inhibitory zone diameter with its Pearson correlation value (r) 0,744 and significant value (p) — 0,000. Conclusion: Both of Plumeria rubra leaves extract from aethyl acetat and methanol solvents has antifungal activity in inhibiting Candida albicans growth in Sabouroud Dextrose Agar media.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Extract, Plumeria rubra leaves, maceration, antifungal, Candida albicans, minimum inhibitory concentration.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	25 Jan 2023 08:26
Last Modified:	25 Jan 2023 08:26
URI:	http://repository.unsri.ac.id/id/eprint/87680

Actions (login required)

View Item