OPTIMASI KECEPATAN DAN LAMA PENGADUKAN TERHADAP KARAKTERISASI ETOSOM KLINDAMISIN HCL DENGAN METODE ULTRA TURRAX SERTA UJI STABILITAS METODE ICH Q1A(R2)

SEPTINA, SHERLI and Apriani, Elsa Fitria and Ahmadi, Adik (2023) OPTIMASI KECEPATAN DAN LAMA PENGADUKAN TERHADAP KARAKTERISASI ETOSOM KLINDAMISIN HCL DENGAN METODE ULTRA TURRAX SERTA UJI STABILITAS METODE ICH Q1A(R2). Undergraduate thesis, Sriwijaya University.

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Abstract

Clindamycin HCl has problem of penetration into the skin, only 1% to 3% of the applied dose of clindamycin HCl can be absorbed into the skin for 24 hours so that ethosomes are expected to be a delivering clindamycin HCl in penetration into the skin with the ability to fusion with skin lipids and high deformability. This study aims to optimize the ethosomes formula for clindamycin HCl with variations in stirring speed and stirring time of ultra turrax with 22 factorial design method to obtain the best ethosom characterization including entrapment efficiency, particle size, polydispersity index, and zeta potential. The optimum formula was tested for standard ICH Q1A(R2) stability using accelerated test. Stirring speed, stirring time, and the interaction both have a significant positive effect on encapsulation efficiency and particle size, but for the polydispersity index only stirring speed has a significant positive effect, while for zeta potential, stirring speed and stirring time have a significant positive value, and the interaction both have a significant negative effect. The optimum formula was obtained at stirring speed of 7,600 rpm and stirring time of 15 minutes with encapsulation efficiency percentage of 72.382 ± 0.360, a particle size of 270.8 ± 8.686 nm, a polydispersity index of 0.111 ± 0.0317, and a zeta potential of -31.21 ± 0.842 mV. The results of the stability of the Q1A(R2) standard showed that ethosomes release model followed zero order, the activation energy 4.232 cal/mol, the kinetic constant 9.897/day with a shelf life 7.293 days at 25℃±2℃ /60% RH±5% RH and shelf life at 5℃±3℃ in 8,247 days.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Klindamisin HCl, Etosom, Optimasi, Desain Faktorial
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Sherli Septina
Date Deposited:	02 Feb 2023 02:44
Last Modified:	02 Feb 2023 02:44
URI:	http://repository.unsri.ac.id/id/eprint/89040

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