UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI N-HEKSANA DAUN UBI JALAR UNGU ( Ipomoea batatas (L.) Lam.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI SUPLEMEN TINGGI LEMAK

FIRLIANI, SHULFA and Solihah, Indah and Agustiarini, Vitri (2022) UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI N-HEKSANA DAUN UBI JALAR UNGU ( Ipomoea batatas (L.) Lam.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI SUPLEMEN TINGGI LEMAK. Undergraduate thesis, Sriwijaya University.

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Abstract

Purple sweet potato (Ipomoea batatas (L.) Lam.) leaf contain beta carotene compounds which have antihyperlipidemia activity. This study aims to determine the antihyperlipidemia effect of n-hexane fraction of purple sweet potato leaves on total cholesterol, triglyceride, HDL and LDL levels in rat serum induced by PTU and high fat supplements. This study divided into 6 groups, normal group, positive group (Fenofibrate dose 19,76 mg/kgBB) , negative group (0.5% NaCMC), group 1 (50 mg/kgBB), group 2 (100 mg/kgBB), and group 3 (200 mg/kgBB). Parameters measured in the form of total cholesterol levels, triglycerides, LDL and HDL were carried out by an enzymatic colorimetric method using the glycerol phospate oxidase p-aminophenazone (GPO-PAP) reagent for triglycerides, cholesterol oxidase p-aminoantipyrine (CHOD-PAP) reagents for total cholesterol, precipitation methods for HDL, indirect for LDL. Based on the results of the research that has been done show that the %PKKT in groups 1, 2 and 3 amounted to 22.2%, 43.3% and 52.8%. Group 3 with dose of 200 mg/kgBB had the best antihyperlipidemia activity among the 3 treatment groups with a decrease in total cholesterol levels of 52.8%. The analysis results obtained showed a decrease in lipid levels and there was a significant difference compared to the negative group (p<0,05). Based on the relationship between the percentage decrease in hyperlipidemia parameters, the effective dose (ED50) of the n-hexane fraction of purple sweet potato leaves was 139,7 mg/kgBB. The result of macroscopic observations of the liver showed that with a dose of 200 mg / kgBB, it had brownish-red heart color, chewy texture, and there is no balloning, and histopathologically it has improved necrosis and steatosis.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antihiperlipidemia, ED50, fraksi n-heksana, histopatologi, Ipomoea batatas (L.) Lam.
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Shulfa Firliani
Date Deposited:	03 Feb 2023 05:58
Last Modified:	03 Feb 2023 05:58
URI:	http://repository.unsri.ac.id/id/eprint/89100

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