UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL DAUN SEMPRAWANG (Dillenia ochreata) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE HOT PLATE

GHANIYA, FAHDELLA and Muharni, Muharni and Fitrya, Fitrya (2023) UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL DAUN SEMPRAWANG (Dillenia ochreata) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE HOT PLATE. Undergraduate thesis, Sriwijaya University.

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Abstract

The ethanol extract of Dillenia ochreata leaves contains secondary metabolites such as triterpenoids, steroids, phenolics and flavonoids which have potential as analgesics with the ability to inhibit prostaglandins as the main mediators of pain. The aims of this study to determine the best dose of the ethanol extract from D. ochreata leaves through the hot plate test, to determine the location of action of the ethanol extract from D. ochreata leaves through the formalin test and to determine the analgesic action of the ethanol extract from D. ochreata leaves through multiple receptors. Analgesic test by hot plate method uses 25 male Wistar rats which were divided into 5 treatment groups. The negative control group was given 1% Na CMC, the positive control group was given 4.5 mg/Kg BW diclofenac sodium, and the test group was given D. ochreata ethanol extract leaves at doses of 100, 200, and 400 mg/KgBW. While the formalin method and evaluation of the mechanism action of analgesics through 3 receptors each used 12 male white rats with 2 treatment groups. Research shows that the ethanol extract of D. ochreata leaves had significant analgesic action by ANOVA (p<0.05) when tested by hot plate and formalin method. The observation results of the hot plate test in the positive control group, the D. ochreata ethanol extract leaves test group at doses of 100, 200 and 400 mg/KgBW obtained the percentage of analgesic activity respectively 18.32%; 9.68%; 15.62%; and 24.85%. The dose of 400mg/KgBW is the best dose that can suppress neurogenic pain (46.92%) and inflammation (61.19%) in the formalin test caused by the mechanism of the opioid receptor. It can be concluded that D. ochreata leaves can contribute as an alternative drug for analgesics.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Dillenia ochreata, analgetik, tes hot plate , tes formalin , reseptor
Subjects: R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Fahdella Ghaniya
Date Deposited: 07 Feb 2023 05:07
Last Modified: 07 Feb 2023 05:07
URI: http://repository.unsri.ac.id/id/eprint/89292

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