UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN SUNGKAI (Peronema canescens Jack) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE HOT PLATE

CENORA, CINDY and Muharni, Muharni and Amriani, Annisa (2023) UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN SUNGKAI (Peronema canescens Jack) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE HOT PLATE. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061281924029.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061281924029_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
Preview	Text RAMA_48201_08061281924029_004036903_0029128405_01_front_Ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (667kB) | Preview
	Text RAMA_48201_08061281924029_004036903_0029128405_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (832kB) | Request a copy
	Text RAMA_48201_08061281924029_004036903_0029128405_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (274kB) | Request a copy
	Text RAMA_48201_08061281924029_004036903_0029128405_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (201kB) | Request a copy
	Text RAMA_48201_08061281924029_004036903_0029128405_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (33kB) | Request a copy
	Text RAMA_48201_08061281924029_004036903_0029128405_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (158kB) | Request a copy
	Text RAMA_48201_08061281924029_004036903_0029128405_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy

Abstract

Pain is a sign that something wrong in the body system such as tissue problem, also it is one of the most complaints when patient sees doctor. Pain can be treated with analgesic drug. One of plant which is widely used as an herbal medicine is Peronema canescens. The leaves of P. canescens has been reported contained betulinic acid, glycoside, β-sitosterol, stigmaterol and phytol. The aims of this research was determined analgesic effect of P. canescens leaves. The leaf was extracted by maceration method using ethanol 96% solvent. The analgesic effect was determined by hot plate and formalin method with latency time and licking time as a pain response parameter. The result on the characterization of extract ethanol P. canescens leaf had qulified the requirement. This research showed that ethanol extract of P. canescens leaves at the dose 100, 200 and 400 mg/KgBW has percentage of analgesic 35.28%, 44.23% and 45.16% respectively. Dose 200 and 400 mg/KgBW were better than diclofenac sodium as positive control (percentage of analgesic was 39.93%). Extract ethanol P. canescens leaf can reduced pain only on the second phase of formalin test. Percentage of analgesic with formalin test on the first phase and second phase respectively were 6.25% and 57.79%. Mechanism action of analgesic from extract ethanol P. canescens leaf influenced by dopamin receptor.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Efek analgetik, Peronema canescens, metode hot plate, metode formalin
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Cindy Cenora
Date Deposited:	08 Feb 2023 01:42
Last Modified:	08 Feb 2023 01:42
URI:	http://repository.unsri.ac.id/id/eprint/89299

Actions (login required)

View Item