UJI AKTIVITAS ANTI ALZHEIMER SECARA IN VITRO DENGAN PENGHAMBATAN ENZIM ASETILKOLINESTERASE (AChE) OLEH EKSTRAK ETANOL KULIT BUAH PETAI (Parkia speciosa Hassk.)

YULANRI, DIVA and Fitrya, Fitrya and Fithri, Najma Annuria (2018) UJI AKTIVITAS ANTI ALZHEIMER SECARA IN VITRO DENGAN PENGHAMBATAN ENZIM ASETILKOLINESTERASE (AChE) OLEH EKSTRAK ETANOL KULIT BUAH PETAI (Parkia speciosa Hassk.). Undergraduate thesis, Sriwijaya University.

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Abstract

Petai is one of the plants that have high antioxidant power. High antioxidants are known to potentially act as enzyme inhibitors of acetylcholinesterase, which is one of the causes of Alzheimer's. Antioxidants play a role through cholinesterase and beta amyloid pathways by inhibiting ROS (reactive oxygen species), thereby reducing the breakdown of acetylcholine by acetylcholinesterase enzymes, reducing the production of amyloid precursor proteins, and inhibiting amyloid beta aggregation that can alleviate Alzheimer's symptoms. The study was conducted to find out how anti Alzheimer activity of ethanol extract of petai pods as in vitro test . This research conducted include the standardidation of extracts which aims to determine the quality of the extract used, the determination of total phenolic and flavonoids extract, IC50 antioxidants, and % inhibition of acetylcholinesterase enzyme. Research gives results that the extract has good quality and meets the standardization requirements of the extract. Total phenolics obtained were 272.45 mg/g gallic acid, total flavonoid of extract is 243.2029 mg/g, IC50 antioxidant petai pods is 75.72 μg/mL, and % inhibition of acetylcholinesterase enzyme is 28.49%.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Petai pod, total phenolic, total flavonoid, IC50 antioxidant, %inhibition of acetylcholinesterase enzyme
Subjects: Q Science > QK Botany > QK1-989 Botany
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 26 Jul 2019 03:55
Last Modified: 26 Jul 2019 03:55
URI: http://repository.unsri.ac.id/id/eprint/915

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