PENGARUH DURASI ISKEMIA-REPERFUSI PADA ACUTE KIDNEY INJURY (AKI) TERHADAP GAMBARAN SELULER TUBULOINTERSTISIAL RENALIS, KADAR CYSTATIN C DAN GLOMERULAR FILTRATIONRATE (GFR) PADA TIKUS WISTAR

RAHMAN, AHADI AULIA and Hidayat, Rachmat and Nita, Sri (2019) PENGARUH DURASI ISKEMIA-REPERFUSI PADA ACUTE KIDNEY INJURY (AKI) TERHADAP GAMBARAN SELULER TUBULOINTERSTISIAL RENALIS, KADAR CYSTATIN C DAN GLOMERULAR FILTRATIONRATE (GFR) PADA TIKUS WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Acute Kidney Injury (AKI) is rapid decline in renal function. Most causes of AKI are ischemia/reperfusion which triggers an inflammatory response and causes renal injury. lnflammation is a prolective response and tissue repair, but it can cause fibrosis, which is the normal tissue replaced by an extracellular matrix such as collagen. Damage that occurs in the tubulointerstitial part has a large effect on renal function. Renal function can be measured by GFR using cystatin C. Kidney function can be measured by GFR using cystatin C. The purpose of this study was to determine the effect of ischemia-reperfusion duration in AKI on tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar rats and find out the correlation between tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar Rats. Method: This research is an experimental research using posttest only with a control group design. The object of research is 30 Wistar rats, the study was conducted in animal house and biomolecular laboratory of the Faculty ofMedicine, Sriwijaya University. Tubulointerstitial cellular appearance, cystatin C levels and GFR were assessed by percentage of collagen area fraction, ELISA and Larsson formula. Result: The duration of 30 minutes ischemia and reperfusion 14 days 99.1% affected the percentage of the collagen area fraction, the duration of 120 minutes ischemia and 14 days reperfusion 98.8% influenced the levels of cystatin C and 99.5% influenced GFR. There was a significant correlation between the percentage of collagen area fraction and cystatin C levels (p = 0,0001, r = 0,901), percentage of collagen and GFR area fractions (p = 0,0001, r = -0,834), and cystatin C levels and GFR (p = 0,0001, r = -915). Conclusion: There is effect between the duration of ischemia/reperfusion tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar rats and there is correlation between tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar rats.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	AKI, Collagen, Cystatin C, GFR
Subjects:	R Medicine > RC Internal medicine > RC799-869 Diseases of the digestive system. Gastroenterology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	10 Apr 2023 03:08
Last Modified:	10 Apr 2023 03:08
URI:	http://repository.unsri.ac.id/id/eprint/93754

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