OPTIMASI KONSENTRASI TWEEN 80 DAN PEG-400 DALAM SEDIAAN NANOEMULSI DAUN SAMBILOTO (Andrographis paniculata (Burm.f.) Wall. Ex Ness) SEBAGAI AGEN FOTOPROTEKTIF

AL RASYID, RIDA SERANITA and Apriani, Elsa Fitria and Hardestyariki, Dwi (2023) OPTIMASI KONSENTRASI TWEEN 80 DAN PEG-400 DALAM SEDIAAN NANOEMULSI DAUN SAMBILOTO (Andrographis paniculata (Burm.f.) Wall. Ex Ness) SEBAGAI AGEN FOTOPROTEKTIF. Undergraduate thesis, Sriwijaya University.

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Abstract

Sambiloto leaves (Andrographis paniculata (Burm. f.) Wall. Ex Ness) has the potential as a photoprotective agent with a high content of quercetin and andrographolide. The preparation of Sambiloto leaves nanoemulsion was carried out to increase its photoprotective activity and stability. This study aims to determine the optimum concentration of Tween 80 and PEG-400 in the Sambiloto leaves nanoemulsion preparation, as well as to determine their photoprotective activity and stability. Optimization using factorial design 22 method through Design Expert 12® response to pH, density, viscosity and percent transmittance. The optimum formula obtained was subjected to particle characterization, SPF and antioxidant activity tests, cycling test and centrifugation test. The optimum Sambiloto leaves nanoemulsion was at a concentration of Tween 80 15% and PEG-400 25%. The result of optimum formula particle size is 172.433 ± 24.312 nm, PDI is 0.245 ± 0.060 and zeta potential is -18.100 ± 0,755 mV. The optimum formula for Sambiloto leaves nanoemulsion has an SPF value of 44.427 ± 0.081 and IC50 124.863 ± 4.045 ppm. The results of the cycling test showed no significant difference (p<0.05) between the results before and after the test on organoleptic, pH, density and percent transmittance parameters. The results of the centrifugation test showed no phase separation. Based on the research results, it was found that the optimum formula of Sambiloto leaves nanoemulsion has strong potential as a photoprotective agent with good particle characteristics and stability.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Nanoemulsi, daun sambiloto, desain faktorial 22, optimasi, fotoprotektif
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Rida Seranita
Date Deposited:	10 Apr 2023 03:52
Last Modified:	10 Apr 2023 03:52
URI:	http://repository.unsri.ac.id/id/eprint/94468

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