POLA KEPEKAAN BAKTERI ESCHERICHIA COLI DARI SPESIMEN URIN TERHADAP ANTIBIOTIK DI RSUP DR. MOHAMMAD HOESIN PALEMBANG PERIODE JUNI 2022-MEI 2023

SARAGIH, DINDA AZZAHRAH and Nawawi, Rizki Andini and Rivani, Erizka (2023) POLA KEPEKAAN BAKTERI ESCHERICHIA COLI DARI SPESIMEN URIN TERHADAP ANTIBIOTIK DI RSUP DR. MOHAMMAD HOESIN PALEMBANG PERIODE JUNI 2022-MEI 2023. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Escherichia coli is a normal flora that commonly resides in the human gut. This bacterium can turn into a pathogen if it gets additional virulence gene transfer from other bacteria. E. coli is among the Enterobactericeae that produce the most Extended-spectrum beta-lactamase (ESBL) that can cause resistance to various types of antibiotics, especially β-lactams, monobactams, and carbapenems (CRE). E. coli is the main cause of urinary tract infections, so urine culture is needed to check for the presence of bacterial colonization. Characteristics related to age, gender, treatment room, catheter use, history of antibiotic use are needed as support in preventing and treating infectious diseases caused by E. coli. Methods: This study used descriptive observational research with a total sampling method, namely observing secondary data through laboratory data and patient medical records at Dr. Mohammad Hoesin Palembang Hospital for the period June 2022 - May 2023. Results: This study obtained a total sample of 196 patients who met the inclusion criteria. This prevalence is grouped into Non ESBL-Non CRE Escherichia coli (26%), ESBL producers (73%), CRE (1%), and ESBL CRE (0%). The highest number of patients aged 19-60 years were 55 (38.5%) samples and 105 (73.4%) samples were female. Based on the treatment room, it was found that more patients were in non-intensive inpatient rooms and did not use catheters (74.1%). Patients with no history of antibiotic use (35%) were more than those who used antibiotics, but patients with the most antibiotics were given sefalosporin, namely 40 (28%) samples. Tigecycline and meropenem were the antibiotics with the highest sensitivity values (99.3%) and ampicillin (AMP) was the most resistant antibiotic (99.3%). Conclusion: Patients with Escherichia coli infections were mostly ESBL producers, women aged 19-60 years and were in non-intensive care rooms. Many patients with these infections did not use catheters and did not take antibiotics, while the antibiotics tested were most sensitive to tigecycline and meropenem and resistant to ampicillin (AMP). Keywords: Escherichia coli, ESBL, CRE, Antibiotic Resistance Testing

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Escherichia coli, ESBL, CRE, Uji Resistensi Antibiotik
Subjects:	R Medicine > RC Internal medicine > RC109-216 Infectious and parasitic diseases
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Dinda Azzahrah Saragih
Date Deposited:	31 Dec 2023 01:12
Last Modified:	31 Dec 2023 01:12
URI:	http://repository.unsri.ac.id/id/eprint/137265

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