UJI AKTIVITAS PENINGKATAN DAYA INGAT EKSTRAK AIR DAUN GAMBIR (UNCARIA GAMBIR ROXB.) TERHADAP MENCIT JANTAN PUTIH GALUR SWISS-WEBSTER

ETNADIO, MUHAMMAD RIZKY and Herlina, Herlina and Novita, Rennie Puspa (2019) UJI AKTIVITAS PENINGKATAN DAYA INGAT EKSTRAK AIR DAUN GAMBIR (UNCARIA GAMBIR ROXB.) TERHADAP MENCIT JANTAN PUTIH GALUR SWISS-WEBSTER. Undergraduate thesis, Sriwijaya University.

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Abstract

A study have been done to investigate the effect of aqueous extract of gambir leaf (Uncaria gambir Roxb.) on memory enhancement of white male mice of Swiss-Webster strain which inhibited with scopolamine using passive avoidance test method. The experimental study used 30 mice divided into 6 groups, which were untreated normal group, positive control group given 500 mg/kgBW piracetam, negative control group given 1% sodium CMC suspension, and treatment group 1, treatment 2, treatment 3 were each given aqueous extract of gambir leaf with dose of 200, 400, and 800 mg/kgBW orally for 21 days. Retention duration data obtained was analyzed by one-way ANOVA and continued with LSD test with 95% confidence level. The results showed that aqueous extract of gambir leaf dose 200, 400, and 800 mg/kgBW have increased memory function, it marked by has no significant difference (p>0.05) with positive control group but is difference (p<0.05) with negative control group and normal control group. Based on the result of the research, it can be concluded that aqueous extract of gambir leaf dose 200, 400, and 800 mg/kgBW give effect to improve the memory of mice induced by scopolamine, with dose 200 mg/kgBW show the most optimal effect.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	gambir leaf, memory enhancement, passive avoidance test
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Administrator Library
Date Deposited:	31 Jul 2019 05:28
Last Modified:	02 Aug 2019 07:13
URI:	http://repository.unsri.ac.id/id/eprint/1375

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