STANDARDISASI DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TEKELAN (CHROMOLAENA ODORATA (L.) R.M. KING & H. ROB.) TERHADAP PROPIONIBACTERIUM ACNES DAN STAPHYLOCOCCUS EPIDERMIDIS

AFRIYANI, NUR and Untari, Budi and Solihah, Indah (2019) STANDARDISASI DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TEKELAN (CHROMOLAENA ODORATA (L.) R.M. KING & H. ROB.) TERHADAP PROPIONIBACTERIUM ACNES DAN STAPHYLOCOCCUS EPIDERMIDIS. Undergraduate thesis, Sriwijaya University.

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Abstract

Tekelan leaves (Chromolaena odorata L.) is one of the traditional medicine from Asteraceae family. This study was conducted to determine the antibacterial activity of tekelan leaves extract concentrations of 5, 10, and 15% of the minimum inhibitory concentration (MIC) against Propionibacterium acnes and Staphylococcus epidermidis after macerated with a solvent n-hexane, ethyl acetate, and 96% ethanol on solvents also to determine the standardization parameter value of the extract. This study is using agar diffusion method with paper discs for testing antibacterial activity. Extract with the smallest MIC was selected to be standardized. The standardization test includes specific and non-specific parameter. The minimum inhibitory concentration (MIC) of ethyl acetate, ethanol, and n-hexan extract i.e 2%, 5% and 8%. The result of the standardization of ethyl acetate extract through a specific parameter test showed that the extract thick, blackish-green, typical smell, and the taste bitter taste. Content of extract soluble in water of 13.3% ± 4.16% and content of extract soluble in ethanol of 23.5% ± 2%. Meanwhile, the result through a non-specific parameter test of ethyl acetate showed that the total ash content of 6.16% ± 1.60%, ash content insoluble in acid 0,65% ± 0% drying shrink age of 34.95% ± 1.37%, and a specific gravity of 0.93 ± 0%.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Chromolaena odorata L., Antibacterial, standardization.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Administrator Library
Date Deposited:	01 Aug 2019 12:15
Last Modified:	02 Aug 2019 06:21
URI:	http://repository.unsri.ac.id/id/eprint/1445

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