REAKSI AMIDASI ASAM URSOLAT[ASAM OLEANOLAT] DARI TRITERPENOID BUAH TEMBESU (Fragraea Fragrans Roxb.) SERTA EVALUASI ANTI KANKER LEUKEMIA P-388 SECARA IN-VITRO

SAPUTRA, ADI and Basir, Dasril and Julinar, Julinar (2015) REAKSI AMIDASI ASAM URSOLAT[ASAM OLEANOLAT] DARI TRITERPENOID BUAH TEMBESU (Fragraea Fragrans Roxb.) SERTA EVALUASI ANTI KANKER LEUKEMIA P-388 SECARA IN-VITRO. Undergraduate thesis, Sriwijaya University.

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Abstract

Amidation reaction of ursolic acid[oleanolic acid] was isolated from tembesu fruits have been conducted by using SOCl2 and butylamine in free solvent condition to obtain N-butyl-urs-2,12-dien-28-amide[N-butyl-olean-2,12-dien-28-amide] with yield 42 %. Cytotoxic activity of amidation product, N-butyl-urs-2,12-dien-28-amide[N-butyl-olean-2,12-dien-28-amide] toward murine cell leukemia P-388 decreasing about half fold compared to starting material ursolic acid[oleanolic acid]. The IC50 value of N-butyl-urs-2,12-dien-28-amide[N-butyl-olean-2,12-dien-28-amide] was 81, 4335 μg/mL whereas the IC50 value of ursolic acid[oleanolic acid] is 53,4 μg/mL.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Tembesu, ursolic acid[oleanolic acid], amidation, free solvent, cytotoxic activity
Subjects: Q Science > QD Chemistry > QD241-441 Organic chemistry
Q Science > QD Chemistry > QD71-142 Analytical chemistry
R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions: 08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 09 Dec 2019 03:56
Last Modified: 09 Dec 2019 03:56
URI: http://repository.unsri.ac.id/id/eprint/20699

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