PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) PEMBAWA AZITROMISIN DENGAN STABILIZER POLY(VINYL ALCOHOL)

YOSUA H., JEFFRY and Mardiyanto, Mardiyanto and Fithri, Najma Annuria (2016) PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) PEMBAWA AZITROMISIN DENGAN STABILIZER POLY(VINYL ALCOHOL). Undergraduate thesis, Sriwijaya University.

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Abstract

Preparation and characterization of submicro particle Poly(Lactic CoGlycolic Acid) (PLGA) hich loads azithromycin with stabilizer Polyvinyl Alcohol (PVA) are able to improve the bioavailability of medicine from class II Biopharmaceutics Classification System (BCS) azithromycin. Submicro PLGAazithromycin preparation was conducted using emulsion solvent evaporation method with different variation of PVA concentration for F1 (40 mg), F2 (50 mg), and F3 (60 mg). The determination of optimum formula is obtained through the Encapsulation Efficiency percentage test (% EE) using spectrophotometer UVVis. The best EE percent of the three formulas was show by F1 which obtained value was 94,751 ± 0,212 %, while F2 and F3 was 90,594 ± 0,385 % and 90,594 ± 0,227 % respectively. The results obtained from diameter testing, PDI, and potential zeta on F1 are 246 nm, 0,202, and -8,2 mV. Morphologic particle determination on F1 provides spherical particle. Stability test showed that submicro PLGA-azithromycin is more stable in pH 5,6 marked by diameter change, size distribution, and zeta potential which changed to 10 nm, 0,08, and - 1,9 mV during the 14 days observation. F1 dissolution analysis indicates that the result of dissolution efficiency percent is 86,473 ± 1,737 %, while the result of conventional azithromycin is 4,019 ± 0,091 %. Submicro size (200 – 500 nm) of PLGA-azithromycin is able to increase the rate of medicine release inside the body which can increase the bioavailability of the medicine. The drug release of submicro PLGA-azithromycin and conventional follows orde 0. Mechanism release of PLGA-azithromycin followed super case-II transport model, and conventional azithromycin ensue anomalous transport model.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Azithromycin, PLGA, PVA, Submicron Particles, Dissolution
Subjects: R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica
R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 10 Dec 2019 02:32
Last Modified: 10 Dec 2019 02:32
URI: http://repository.unsri.ac.id/id/eprint/20948

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