Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Elfita, Elfita and Muharni, Muharni and Latief, Madyawati and Darwati, Darwati and Widiyantoro, Ari and Supriyatna, Supriyatna and Bahti, Husein H. and Dachriyanus, Dachriyanus and Cos, Paul and Maes, Louis and Foubert, Kenne and Apers, Sandra and Pieters, Luc Antiplasmodial and other constituents from four Indonesian Garcinia spp. Phytochemistry, The International Journal of Plant Chemistry, Plant Biochemistry and Molecular Biology., 70 (7). pp. 907-912. ISSN 0031-9422

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Abstract

Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, \ensuremathβ-sitosterol-3-O-\ensuremathβ-d-glucoside and stigmasterol-3-O-\ensuremathβ-d-glucoside from the stem bark of G. griffithii; friedelin and 3\ensuremathβ-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (±)-morelloflavone, morelloflavone-7-O-\ensuremathβ-d-glucoside or fukugiside, the triterpene 3\ensuremathβ-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene \ensuremathβ-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.

Item Type:	Article
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User:	backup admin
Date Deposited:	10 Jan 2020 08:05
Last Modified:	17 Jan 2020 03:26
URI:	http://repository.unsri.ac.id/id/eprint/22566

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