Correlation Between Hypoxia Inducible Factor-1\ensuremathα and Vesicular Endothelial Growth Factor in Male Wistar Rat Brain Tissue After Anaerobic Exercise

Flora, Rostika Correlation Between Hypoxia Inducible Factor-1\ensuremathα and Vesicular Endothelial Growth Factor in Male Wistar Rat Brain Tissue After Anaerobic Exercise. Trends in Medical Research. ISSN 1819-3587

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Abstract

During physical activity, oxygen reduction leading to hypoxia affects brain cell metabolisms, induces stabilization of Hypoxia Inducible Factor-1\ensuremathα (HIF-1\ensuremathα) and up-regulate Vesicular Endothelial Growth Factor (VEGF). This study aimed to investigate the correlation of HIF-1\ensuremathα and VEGF of brain tissue in male wistar rat after anaerobic exercise. Twenty four rats were divided into four groups: control, 1x, 3x and 7x in a week of anaerobic exercise. A rat treadmill was used at speed 35 m minG1, 20 min for every anaerobic exercise. The HIF-1\ensuremathα and VEGF level were measured by ELISA. The correlation between HIF-1\ensuremathα and VEGF was analyzed using Pearson test. The HIF-1\ensuremathα and VEGF level increased in 1x and 3x a week of anaerobic exercise. The highest HIF-1\ensuremathα and VEGF level were observed in 1x a week of anaerobic exercise. Pearson test between HIF-1\ensuremathα and VEGF showed r = 0.709 and p = 0.000. These findings showed that HIF-1\ensuremathα and VEGF are correlated and anaerobic exercise affects HIF-1\ensuremathα and VEGF level

Item Type: Article
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User: backup admin
Date Deposited: 10 Jan 2020 08:05
Last Modified: 17 Jan 2020 03:27
URI: http://repository.unsri.ac.id/id/eprint/22575

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