Deteksi Resistensi Plasmodium Falciparum Terhadap Klorokuin Dengan Marka Situs Polimorfik Lys76Tyr Gen Pfcrt Menggunakan PCR-RFLP

Triwani, Triwani Deteksi Resistensi Plasmodium Falciparum Terhadap Klorokuin Dengan Marka Situs Polimorfik Lys76Tyr Gen Pfcrt Menggunakan PCR-RFLP. Working Paper. Seminar Pandi/Persandi Solo.

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Abstract

Over the past decade, anti-malarial drug resistance has rapidly become a major public health problem in the South East Asia region including South Sumatra. Treatment failures to the first and second lines antimalarial drugs such as chloroquine and combination of sulfadoxin epyrimethamine have increased in the South Sumatera Province, Indonesia. A molecular epidemiologic study was conducted to determine the frequency distribution of mutant alleles of the genes associated with the resistance among the isolates of Plasmodium falciparum from this area. Analyses using a polymerase chain reaction and restriction fragment length polymorphism showed that nearly all of the 6 samples carried mutant alleles in genes associated with chloroquine resistance: P. falciparum chloroquine resistance transporter (pfcrt) Lys76Tyr (100%). These results are consistent with the antimalarial drug resistance situation in the area and emphasize the need for a proper treatment strategy.

Item Type: Monograph (Working Paper)
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User: backup admin
Date Deposited: 10 Jan 2020 08:06
Last Modified: 17 Jan 2020 03:30
URI: http://repository.unsri.ac.id/id/eprint/22581

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