Peer Reviewer_Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspnea

Legiran, Legiran (2017) Peer Reviewer_Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspnea. Paediatrica Indonesiana.

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Abstract

Background Malnutrition in hospitalized children has negative Background Dyspnea can be caused by various conditions, one of which is cardiac abnormality. Physical examination alone is not sufficient for distinguishing breathing ailments caused by heart abnormalities, especially in small children. N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used as a marker of heart disease. Objective To evaluate the usefulness of NT-proBNP levels as a screening tool to diagnose cardiac abnormalities in children pre - senting with dyspnea. Methods A cross-sectional study was conducted from August to October 2015 in pediatric patients aged 1 month to 18 years pre - senting with dyspnea in the Pediatric Ward, Mohammad Hoesin Hospital, Palembang, North Sumatera. All subjects provided blood specimens for NT-proBNP examinations and underwent echocar - diography to assess for the presence of cardiac abnormalities. The diagnostic value was analyzed by ROC curve. We determined the optimal cut-off point, sensitivity, and specificity. Results Fifty-eight subjects, with median age 9.5 (range 1-180) months, consisted of 39 children with and 19 children without cardiac abnormalities. Subjects’ median NT-proBNP levels were significantly higher in those with cardiac abnormalities than in those without [1,775 (range 189-9,000) pg/mL vs. 759 (range 245-9,000) pg/mL, respectively, (P=0.002)]. In a ROC curve analysis, the AUC value was 0.75, and at the optimal cut-off point of 1,235 pg/ml had sensitivity of 74.4% and specificity of 73.7%. Conclusion The level of NT-proBNP can be used to screen for cardiac abnormalities in children presenting with dyspnea.

Item Type: Other
Subjects: #3 Repository of Lecturer Academic Credit Systems (TPAK) > Results of Peer Review
Divisions: Faculty of Medicine > 11901-Doctor Profession (Profesi)
Depositing User: dr Legiran Legiran
Date Deposited: 22 May 2020 13:38
Last Modified: 22 May 2020 13:38
URI: http://repository.unsri.ac.id/id/eprint/29392

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