OPTIMASI DAN KARAKTERISASI SOLID LIPID NANOPARTIKEL EKSTRAK ETANOL KULIT BUAH Parkia speciosa DENGAN VARIASI KONSENTRASI SURFAKTAN, SUHU PEMBUATAN, DAN KECEPATAN PENGADUKAN

SEPTIANAH, EVI and Fitrya, Fitrya and Fithri, Najma Annuria (2018) OPTIMASI DAN KARAKTERISASI SOLID LIPID NANOPARTIKEL EKSTRAK ETANOL KULIT BUAH Parkia speciosa DENGAN VARIASI KONSENTRASI SURFAKTAN, SUHU PEMBUATAN, DAN KECEPATAN PENGADUKAN. Undergraduate thesis, Sriwijaya University.

[img]
Preview
Text
RAMA_48201_08061181419022_0010127203_01_front_ref.pdf - Accepted Version
Available under License Creative Commons Public Domain Dedication.

Download (1MB) | Preview
[img] Text
RAMA_48201_08061181419022_0010127203_02.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (795kB) | Request a copy
[img] Text
RAMA_48201_08061181419022_0010127203_03.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (482kB) | Request a copy
[img] Text
RAMA_48201_08061181419022_0010127203_04.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (976kB) | Request a copy
[img] Text
RAMA_48201_08061181419022_0010127203_05.pdf - Accepted Version
Restricted to Registered users only
Available under License Creative Commons Public Domain Dedication.

Download (152kB) | Request a copy
[img] Text
RAMA_48201_08061181419022_0010127203_06_ref.pdf - Bibliography
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (405kB) | Request a copy
[img] Text
RAMA_48201_08061181419022_0010127203_07_lamp.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (3MB) | Request a copy

Abstract

The ethanol extract of petai pods contains of polyphenolic compounds, tannins, and flavonoids that are efficacious as antioxidants. Solid lipid nanoparticle (SLN) preparation formula aims to increase penetration through the stratum corneum. Preparations are formulated using solid lipid of cetyl alcohol, tween-80 surfactant, and propylene glycol co-surfactant. Variations in surfactant concentration, manufacture temperature, and stirring rate were used as factors with factorial design 23 in the Design Expert®10. Effect of factors composition and interaction was observed based on the results of the percentage efficiency entrapment (% EE), stability, pH, organoleptic, and hedonic. Results of the test analysis using Design Expert®10 yielded the optimum formula with the proportion of tween-80 0,704 mL, the temperature of manufacture of 60oC, and the speed of stirring 1000 rpm. Result of analysis % EE, particle size, polydispersity index (PDI), zeta potential, and viscosity are 88.808 ± 0.058; 393.8 nm; 0.421; -1.7 mV; and 2 cP. Qualitative testing of antioxidants using DPPH reagent showed SLN extract of ethanol pod of petai has positive antioxidant activity. Stability analysis using the thermodynamic method using temperature 4 ± 2oC and 40 ± 2oC for 6 cycles showed that optimum formula of SLN is more stable than pure extract. The percent diffusion measurements of the optimum formula and pure extract at 480 min were 9.830 ± 0.0114% and 4.484 ± 0.0219% indicating SLN penetration ability more bigger than ethanol extract of pod petai in carrier fluid. Compartemental analysis with WinSAAMTM software yielded the optimum formula following the compartment lag model with the correlation between Qo and Qc with p-value<0,05. The interaction studies of ethanol extracts pods petai and excipients using FTIR showed no chemical interactions. Based on the results of the research, ethanol extract of pod petai can be made in solid lipid nanoparticle

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: ethanol extract of pods petai, Parkia speciosa, solid lipid nanoparticles, cetyl alcohol, tween-80
Subjects: R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 09 Aug 2019 04:09
Last Modified: 09 Aug 2019 04:09
URI: http://repository.unsri.ac.id/id/eprint/3287

Actions (login required)

View Item View Item