AKTIVITAS ANTIDIARE KOMBINASI FRAKSI N-HEKSANA DAN ETIL ASETAT DAUN KARAMUNTING (Rhodomyrtus tomentosa (Ait.) Hassk.) PADA TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI BAKTERI Salmonella typhi

PRATIWI, ROSITA SEPTIANA AYU and Salni, Salni and Herlina, Herlina (2020) AKTIVITAS ANTIDIARE KOMBINASI FRAKSI N-HEKSANA DAN ETIL ASETAT DAUN KARAMUNTING (Rhodomyrtus tomentosa (Ait.) Hassk.) PADA TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI BAKTERI Salmonella typhi. Undergraduate thesis, Sriwijaya University.

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Abstract

The in vivo antidiarrheal activity test of the combination of n-hexane and ethyl acetate fraction of karamunting leaves (Rhodomyrtus tomentosa (Ait.) Hassk.) against Salmonella typhi bacteria was carried out in order to determine the standardization of n-hexane fraction of karamunting leaves and to determine the optimum dose of combination n-hexane and ethyl acetate fractions of karamunting leaves as antidiarrheal. The animal test used male white rats Wistar strains which were divided into 5 groups consisting of a positive control group using a chloramphenicol dose of 25 mg/kg BW, negative control group using 1% Na CMC suspension and a combination treatment group of n-hexane and ethyl acetate fractions of karamunting leaves with variations in the doses of 25, 50, 100 mg/kg BW. The results of the standardization of the n-hexane fraction showed that the moisture content 6.67%; drying loss 7.16%; total ash content 0.95%; acid insoluble ash content 0.61%; water soluble extract content of 3.34%; ethanol soluble extract content 31.67%; microbial contamination test <10 cfu/g; Pb metal contamination test 1.4606 mg/kg; and Cd metal contamination test 0.2189 mg/kg. The fastest returned of feces consistency at dosage combined fraction of 100 mg/kg BW on the 6th day. The combination of fractions at a dose of 25 mg/kg BW and 50 mg/kg BW was able to reduce the number of bacterial colonies to 2.72 x 106 cfu/g and 1.58 x 106 cfu/g, less than the negative control 5.64 x 106 cfu/g. The combination of fractions at a dose of 100 mg/kg BW can reduce the Salmonella typhi bacterial population to zero after 12 days of treatment. This shows that the combination of n-hexane and ethyl acetate fractions of karamunting leaves has better antidiarrheal activity at the highest dose (100 mg/kg BW) and there is no significant difference compared to chloramphenicol at a dose of 25 mg/kg BW (p>0,05).

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Daun karamunting, antidiare, fraksi n-heksana, fraksi etil asetat, Salmonella typhi
Subjects: Q Science > QR Microbiology > QR75-99.5 Bacteria
R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Rosita Septiana Ayu Pratiwi
Date Deposited: 05 Oct 2020 04:45
Last Modified: 05 Oct 2020 04:45
URI: http://repository.unsri.ac.id/id/eprint/36142

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