HUBUNGAN KARAKTERISTIK KLINIKOPATOLOGI SQUAMOUS CELL CARCINOMA (SCC) SERVIKS DENGAN TUMOR-ASSOCIATED NEUTROPHIL (TAN)

Alisa, Nanda Safira and Dewi, Citra and Susilawati, Susilawati (2020) HUBUNGAN KARAKTERISTIK KLINIKOPATOLOGI SQUAMOUS CELL CARCINOMA (SCC) SERVIKS DENGAN TUMOR-ASSOCIATED NEUTROPHIL (TAN). Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Cervical carcinoma is one of the most common cancers in women, according to data from World Health Organization (WHO). Cervical carcinoma ranks the fourth most deadly type of cancer. Cervical carcinoma is a malignant tumor that grows in cervical tissue which is generally caused by Human Papilloma Virus (HPV) types 16 and 18. It is known that neutrophils are one of the most common types of white blood cells are circulating in the human body. Tumor infiltrating neutrophil or Tumor Associated Neutrophil (TAN) are found in various types of cancer, the density of TAN can determine the prognostic type of tumor or cancer in each individual. This study was aimed to identify correlation between clinicopathological characteristics of cervical SCC and TAN ikn cervical SCC patients registered at RSUP Dr. Mohammad Hoesin Palembang. Methods: This type of research is analytic with a cross-sectional method. Data collection in this study used a 37 slides archieve which were diagnosed as cervical squamous cell carcinoma (SCC) were considered in Anatomic Pathology in RSUP Dr. Mohammad Hoesin Palembang for the period 2017-2019. Result: From 37 cervical SCC patients, the clinicopathological characteristics of the majority of cervical SCC patients occurred in the age group \geq51 (51.4%), with histopathological non-keratinizing SCC (75,7%) and the highest differentiation degree that was moderately differentiated (75,7%). The TAN density was mostly found at low TAN densities (73%). There was significant correlation between ages and TAN density (p=0.035) and there was no significant correlation between age and TAN density (p=0.269). Conclusion: It was explained that he higher the degree of differentiation, the lower the TAN density value, but in this study the neutrophil count was not yet certain whether it was anti-tumor (N1) or pro-tumor (N2) Key words: cervical squamous cell carcinoma, Tumor Associated Neutrophil, clinicopathological characteristics, prognostic.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Squamous Cell Carcinoma serviks, Tumor Associated Neutrophil, karakteristik klinikopatologi, prognostik
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
R Medicine > RB Pathology > RB24-33 Pathological anatomy and histology
Divisions: Faculty of Medicine > 11201-Medicine (S1)
Depositing User: Nanda Safira Alisa
Date Deposited: 11 Jan 2021 05:05
Last Modified: 11 Jan 2021 05:05
URI: http://repository.unsri.ac.id/id/eprint/39626

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