HUBUNGAN POLIMORFISME TITIK -3575 PROMOTER DISTAL GEN IL-10 TERHADAP KERENTANAN PENYAKIT KUSTA PADA PASIEN KUSTA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

SYAFIRA, FARA and Oktariana, Desi and Rahadiyanto, Kemas Yakub (2021) HUBUNGAN POLIMORFISME TITIK -3575 PROMOTER DISTAL GEN IL-10 TERHADAP KERENTANAN PENYAKIT KUSTA PADA PASIEN KUSTA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011181823033.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_11201_04011181823033_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (11MB) | Request a copy
Preview	Text RAMA_11201_04011181823033_0013109001_0012017201_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview
	Text RAMA_11201_04011181823033_0013109001_0012017201_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011181823033_0013109001_0012017201_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011181823033_0013109001_0012017201_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011181823033_0013109001_0012017201_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011181823033_0013109001_0012017201_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011181823033_0013109001_0012017201_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy

Abstract

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. However, of all individuals exposed to M. leprae, only 0.1–1% developed leprosy. There is an important role of host genetics that will affect the condition of the immune system in determining the pathogenesis of leprosy. IL-10 is an anti-inflammatory and pro-inflammatory cytokine that plays a central role in infectious diseases, especially leprosy. Polymorphisms in the promoter region can affect the amount of IL-10 secretion by influencing the level of IL-10 transcription. The amount of IL�10 secretion determines the body's response to M. leprae susceptibility and resistance. The purpose of this study was to determine the association of -3575 IL�10 gene promoter polymorphysm with susceptibility to leprosy in RSUP Dr. Mohammad Hoesin Palembang. This type of research is observational analytic with a case-control approach. Identification of polymorphisms using the PCR-RFLP technique. The samples identified were 50 DNA samples from leprosy patients and 50 DNA samples from healthy people who were not diagnosed with leprosy in RSUP dr. Mohammad Hoesin Palembang period January – February 2019. A total of 50 case samples and 50 control samples were identified. The majority of genotypes and alleles in samples of leprosy patients and controls are a homozygous wild-type (TT) genotype and a wild-type (T) allele. There was no significant association between genotype and leprosy p (1,000) > 0.05, PB type leprosy p (0,514) > 0.05, and MB type leprosy p (1,000) > 0.05 in leprosy patients and controls. There was no significant association between alleles for leprosy p (1,000) > 0.05, PB type leprosy p (0.514) > 0.05, and MB type leprosy p (1,000) > 0.05 in leprosy patients and controls. It can be concluded that there was no association of -3575 IL-10 gene promoter polymorphysm with susceptibility to leprosy in RSUP Dr. Mohammad Hoesin Palembang.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kusta, Polimorfisme, Gen IL-10, Titik -3575
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	FARA SYAFIRA
Date Deposited:	30 Dec 2021 03:30
Last Modified:	30 Dec 2021 03:30
URI:	http://repository.unsri.ac.id/id/eprint/60268

Actions (login required)

View Item