Gambaran Polimorfisme Titik -308 Promoter Gen TNF-α dan Kadar Antibodi Pasca Pemberian Vaksin Inaktif COVID-19 Dosis Kedua

AFLADHANTI, PUTRI MAHIRAH and Amalia, Ella and Diba, Masayu Farah (2021) Gambaran Polimorfisme Titik -308 Promoter Gen TNF-α dan Kadar Antibodi Pasca Pemberian Vaksin Inaktif COVID-19 Dosis Kedua. Undergraduate thesis, Sriwijaya University.

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Abstract

COVID-19 vaccination is a COVID-19 long-term prevention and control strategies which currently done by the government. COVID-19 vaccination is useful for inducing significantly neutralizing antibody levels and triggering a memory response to SARS-CoV-2. The effectiveness of vaccination is influenced by various factors, one of which is genetics. Previous studies have reported the association of -308 TNF-α gene promoter polymorphism with increased production of TNF-α as a central mediator of immune response. This study aimed to describe the -308 TNF-α gene promoter polymorphism and antibody concentration post second dose COVID-19 vaccination with inactivated vaccine. This research is an observational descriptive study using PCR-RFLP method and primary data collection of IgG s1 RBD SARS-CoV-2 concentration. The sample was Palembang citizen from several institutions who had been vaccinated with the second dose of inactivated COVID-19 vaccine on March – August 2021. Data analysis was carried out using SPSS 25 to assess the frequency distribution of genotype and allele at -308 TNF-α gene promoter and antibody concentration. The results showed a total of 55 samples were identified. Most subjects were 17-25 years old (43.6%) and female (52.7%). From the PCR-RFLP results, the genotype frequency distribution of GG 85.5%, GA 12.7%, and AA 1.8%. The G allele was found in 91.8% and the A allele was 8.2%. Meanwhile, data on antibody concentration using CMIA method showed 43.6% had high antibody concentration and 56.4% had low antibody concentration.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Polimorfisme, titik-308, gen TNF-α, kadar antibodi, pasca vaksinasi, vaksin COVID-19
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Putri Mahirah Afladhanti
Date Deposited:	30 Dec 2021 04:33
Last Modified:	30 Dec 2021 04:33
URI:	http://repository.unsri.ac.id/id/eprint/60274

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