HUBUNGAN MICROVESSEL DENSITY DENGAN KARAKTERISTIK KLINIKOHISTOPATOLOGI PADA HODGKIN LYMPHOMA DI BAGIAN PATOLOGI ANATOMI RSUP DR. MOHAMMAD HOESIN PALEMBANG

ZULFIKAR, M. BIMA and Murti, Krisna and Liberty, Iche Andriyani (2021) HUBUNGAN MICROVESSEL DENSITY DENGAN KARAKTERISTIK KLINIKOHISTOPATOLOGI PADA HODGKIN LYMPHOMA DI BAGIAN PATOLOGI ANATOMI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Angiogenesis is the process of new blood vessel growth that has an important role in tumor development. One method to assess angiogenesis is to measure microvessel density (MVD). A high MVD is associated with a poor prognosis in various types of cancer. The aim of this study was to determine the association between microvessel density and clinicohistopathological characteristics in patients with Hodgkin Lymphoma at the Anatomical Pathology Department, Dr. Mohammad Hoesin Palembang period 2016-2021. The observational analytic study with a cross-sectional method was conducted. The samples were paraffin blocks of patients diagnosed as HL stained immunohistochemistry (IHC) with antibody anti-CD34 at the Anatomical Pathology Department, Dr. Mohammad Hoesin Palembang for the period 2016 – 2021 and has complete clinicohistopathology data according to the criteria in this study. Microvessel was determined by observing the morphology of endothelial and the expression of CD34 in the endothelial cytoplasm and/or cell membrane upon immunostained with anti-CD34 antibody. The result of the MVD calculation was statistically analyzed and associated with the clinicohistopathological characteristics of HL. The results of the study show majority HLs were diagnosed more in the age group of <45 years (71%) male (61.3%), nodal location (80.6%) and LRCHL subtype (51.6%). The distributions of high MVD were more in the age category <45 years, male, nodal location, and LRCHL subtype. There was no significant association between microvessel density and the clinicohistopathological characteristics of HL. Based on the results of the study, there was no significant association between micovessel density and clinicohistopathological characteristics in Hodgkin lymphoma. Keywords: HL, Hodgkin lymphoma, MVD, Angiogenesis, CD34, Clinicohistopathological characteristics

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	HL, Hodgkin lymphoma, MVD, Angiogenesis, CD34, Karakteristik Klinikohistopatologi
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	M. Bima Zulfikar
Date Deposited:	31 Dec 2021 03:34
Last Modified:	31 Dec 2021 03:34
URI:	http://repository.unsri.ac.id/id/eprint/60386

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