UJI AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN DAUN BELUNTAS (Pluchea indica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4

FAUZIAH, HANIAH and Herlina, Herlina and Agustiarini, Vitri (2022) UJI AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN DAUN BELUNTAS (Pluchea indica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061381823088.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
Preview	Text RAMA_48201_08061381823088_0003077102_0016089302_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview
	Text RAMA_48201_08061381823088_0003077102_0016089302_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (357kB) | Request a copy
	Text RAMA_48201_08061381823088_0003077102_0016089302_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (434kB) | Request a copy
	Text RAMA_48201_08061381823088_0003077102_0016089302_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (652kB) | Request a copy
	Text RAMA_48201_08061381823088_0003077102_0016089302_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (91kB) | Request a copy
	Text RAMA_48201_08061381823088_0003077102_0016089302_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (352kB) | Request a copy
	Text RAMA_48201_08061381823088_0003077102_0016089302_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061381823088_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy

Abstract

Beluntas leaf have antioxidant activity by inhibiting lipid peroxidation thereby preventing the formation of malondialdehyde (MDA). The purpose of this study is to determine the effect on antioxidant activity of n-hexane fraction of beluntas leaves by measuring MDA levels, knowing catalase enzyme activity and macroscopic and histopathological features of CCl4-induced rat liver. The treatments were divided into 6 groups, namely normal, negative, positive control group, treatment I with a dose of 10 mg/200gBB, treatment II with a dose of 20 mg/200gBB and treatment III with a dose of 40 mg/200gBB. The average results of MDA levels in the normal, negative, positive groups, given fraction doses of 10, 20 and 40 mg/200gBB, respectively, were 0,677; 2,732; 0,821; 1,112; 0,934 and 0,855 nmol/mL. The average results of the catalase enzyme activity in the normal, negative, positive groups, given fraction doses of 10, 20 and 40 mg/200gBB respectively were 13,081; 4,621; 21,448; 8,6288; 16,751 and 22,200 U/mL. The macroscopic and histopathological results of the liver showed an improvement after being given n-hexane fraction of beluntas leaves at doses of 10, 20 and 40 mg/200gBB when compared to the negative group. The results showed that the ethanolic extract of beluntas leaves significantly could be efficacious as an antioxidant by reducing MDA levels and increasing catalase enzyme activity (p<0,05). Based on Duncan's statistical analysis that there was no significant difference between the ethanol extract of beluntas leaves at a dose of 40 mg/200gBB and the positive control group given vitamin E 1,581 mg/200gBB.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	daun beluntas (Pluchea indica L.), kadar MDA, aktivitas enzim katalase, histopatologi hepar
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Haniah Fauziah
Date Deposited:	10 Aug 2022 07:07
Last Modified:	10 Aug 2022 07:07
URI:	http://repository.unsri.ac.id/id/eprint/76710

Actions (login required)

View Item