FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE PEMBAWA ERITROMISIN DENGAN KOSURFAKTAN PEG 400 DAN VARIASI JUMLAH ASAM STEARAT

ISNANTYO, DHORSAN EGI and Sinulingga, Sadakata and Mardiyanto, Mardiyanto (2022) FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE PEMBAWA ERITROMISIN DENGAN KOSURFAKTAN PEG 400 DAN VARIASI JUMLAH ASAM STEARAT. Undergraduate thesis, Sriwijaya University.

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Abstract

ERYTHROMYCIN IS A DRUG THAT HAS LOW SOLUBILITY IN WATER. THE LOW SOLUBILITY OF THE DRUG CAUSES SLOW ABSORPTION OF THE DRUG IN THE BODY AND RESULTS IN INADEQUATE BIOAVAILABILITY, SO A SOLID LIPID NANOPARTICLE OF ERYTHROMYCIN WAS CARRIED OUT TO INCREASE ITS SOLUBILITY. FORMULA SOLID LIPID NANOPARTICLE CONSISTED OF STEARIC ACID WITH VARIOUS CONCENTRATIONS AS A LIPID MATRIX, TWEEN 80 AS A SURFACTANT, PEG 400 AS A COSURFACTANT, AND PVA AS A STABILIZER. THE STUDY USED 3 FORMULAS TO TAKE THE BEST FORMULA BASED ON %EE AND THEN CARRIED OUT PARTICLE CHARACTERIZATION, PHYSICAL STABILITY TESTING, AND SOLUBILITY TESTING. THE PERCENTAGE OF EE PRODUCED BY FORMULA 1, FORMULA 2, AND FORMULA 3 IS 77.9216 ± 0.2094; 82.755 ± 0.0408; AND 81.255 ± 0.1870. THE RESULTS OF THE BEST FORMULA CHARACTERIZATION, NAMELY FORMULA 2, OBTAINED A PARTICLE SIZE OF 342.8 ± 0.3 NM, PDI 0.215 ± 0.0015; AND ZETA POTENTIAL -18.45 ± 0.15 MV. THE RESULTS OF THE PHYSICAL STABILITY TEST USING THE HEATING COOLING FOR 12 DAYS SHOWED THE RESULTS IN THE FORM OF A WHITE, SLIGHTLY CLOUDY PREPARATION, THE PH DECREASED AND INDICATED THE OCCURRENCE OF PHASE SEPARATION, AS WELL AS PHASE SEPARATION IN THE MECHANICAL STABILITY TEST. THE RESULTS OF THE SOLUBILITY TEST SHOWED THAT THE SOLID LIPID NANOPARTICLE ERYTHROMYCIN WAS COMPLETELY SOLUBLE IN AQUADEST, 5% HCL, SGF AND SIF. BASED ON THE RESULTS OF THE STUDY SHOWED THAT THE SOLUBILITY OF ERYTHROMYCIN CAN BE INCREASED BY BEING FORMULATED INTO SOLID LIPID NANOPARTICLES.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Eritromisin, Solid Lipid Nanoparticle, Asam Stearat, PEG 400, Persen Efisiensi Enkapsulasi
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Dhorsan Egi Isnantyo
Date Deposited:	10 Aug 2022 04:13
Last Modified:	10 Aug 2022 04:13
URI:	http://repository.unsri.ac.id/id/eprint/76987

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