OPTIMASI DAN KARAKTERISASI FITOSOM FRAKSI ETIL ASETAT EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana L.) DENGAN VARIASI KONSENTRASI PHOSPHOLIPON 90G DAN KOLESTEROL

AGUSTRIA, WINDA and Wijaya, Dina Permata and Apriani, Elsa Fitria (2022) OPTIMASI DAN KARAKTERISASI FITOSOM FRAKSI ETIL ASETAT EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana L.) DENGAN VARIASI KONSENTRASI PHOSPHOLIPON 90G DAN KOLESTEROL. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061381813093.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_48201_08061381823093_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
Preview	Text RAMA_48201_08061381823093_0018019204_0010037102_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (6MB) | Preview
	Text RAMA_48201_08061381823093_0018019204_0010037102_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061381823093_0018019204_0010037102_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061381823093_0018019204_0010037102_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061381823093_0018019204_0010037102_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061381823093_0018019204_0010037102_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061381823093_0018019204_0010037102_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy

Abstract

The mangosteen rind (Garcinia mangostana L.) contains xanthone derivative compounds including alpha mangosteen which acts as an antityrosinase. A delivery system such as phytosomes can be added to increase the active substance's penetration. The study aimed to determine the optimum formula for phytosomes with variations in phospholipone 90G and cholesterol. Phytosomes were made using the thin layer hydration method with a ratio of phopholipone 90G and cholesterol concentrations (2:0,2; 1:0,4; 1:0,2; 2:0,4). The optimum formula was determined by a factorial design of 22 using Design-Expert 12® on the response of adsorption efficiency, decrease in adsorption efficiency, and decrease in pH after the stability test. The optimum formula obtained was characterized by particle size, PDI (polydispersity index), and zeta potential. The optimum formula was obtained using 2% phopholipon 90G and 0.2% cholesterol with an adsorption efficiency value of 96.895 ± 0.015, a decrease in adsorption efficiency of 0.703 ± 0.020, and a decrease in pH of 0.026 ± 0.004. The results of the characterization of the optimum formula obtained particle size of 391.6 nm, PDI 0.685, and zeta potential -13.9 mV.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Mangosteen rind, Alfa mangosteen, Phytosomes, Phospholipone 90G, Cholesterol
Subjects:	R Medicine > RS Pharmacy and materia medica > RS125-131.9 Formularies. Collected prescriptions R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Winda Agustria
Date Deposited:	04 Oct 2022 05:11
Last Modified:	04 Oct 2022 05:11
URI:	http://repository.unsri.ac.id/id/eprint/80430

Actions (login required)

View Item