PERBEDAAN INFILTRASI SEL NEUTROFIL BERDASARKAN KARAKTERISTIK KLINIKOHISTOPATOLOGI JARINGAN KARSINOMA OVARIUM TIPE SEROSA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

ZHAFIRAH, AISYAH MULYA and Fertilita, Soilia and Larasati, Veny (2023) PERBEDAAN INFILTRASI SEL NEUTROFIL BERDASARKAN KARAKTERISTIK KLINIKOHISTOPATOLOGI JARINGAN KARSINOMA OVARIUM TIPE SEROSA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Introduction: Ovarian cancer is the main cause of death globally and ranks third as the most common incidence in Indonesian women. Neutrophil cell infiltration in cancer tissue as one of the immune cells that has an important role in the formation of the body's response against cancer but associated with poor prognosis. Neutrophil density is related to the clinicohistopathologic characteristics of ovarian cancer patients. The purpose of this study was to determine the relationship of clinicohistopathologic characteristics with neutrophil cell infiltration of serous type ovarian carcinoma tissue. Methods: This study used a cross-sectional method. The samples used were serous type ovarian carcinoma tissue preparations that had been stained with Hethoxylin-Eosin and clinical data from the Medical Record Installation. Observations were made by identifying neutrophil cells through their morphology that infiltrate the microtumor environment of stromal and intratumoral areas. Results: There were 35 patients diagnosed with serous type ovarian carcinoma. The majority of samples were aged 40-60 years (48.6%) with the most histologic subtype HGSC (74.3%). The majority of the samples were advanced stage (77.1%) with organ metastasis around the pelvis (62.9%). There was no significant difference between neutrophil cell infiltration based on clinicohistopathological characteristics, including age (stromal p=0.845 and intratumoral p=0.223), grading (stromal p=0.299 and intratumoral p=0.720), FIGO stage (stromal p=0.345 and intratumoral p=0.377), and metastasis (stromal p=0.835 and intratumoral p=0.936). Conclusion: There is no significant difference between neutrophil cell infiltration according to location and clinicohistopathological characteristics of serous type ovarian carcinoma tissue at RSUP Dr. Mohammad Hoesin Palembang.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	karsinoma ovarium serosa, lingkungan mikro tumor, sel neutrofil, klinikohistopatologi
Subjects:	R Medicine > R Medicine (General) > R702-703 Medicine and the humanities. Medicine and disease in relation to history, literature, etc. R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Aisyah Mulya Zhafirah
Date Deposited:	31 Dec 2023 01:07
Last Modified:	31 Dec 2023 01:07
URI:	http://repository.unsri.ac.id/id/eprint/137187

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