FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI TRANSDERMAL PATCH FRAKSI ETIL ASETAT DAUN SINGKONG (Manihot esculenta Crantz.) TERHADAP BAKTERI Staphylococcus aureus

PUTERI, RATIKA and Wijaya, Dina Permata and Miksusanti, Miksusanti (2024) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI TRANSDERMAL PATCH FRAKSI ETIL ASETAT DAUN SINGKONG (Manihot esculenta Crantz.) TERHADAP BAKTERI Staphylococcus aureus. Undergraduate thesis, Sriwijaya University.

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Abstract

Fraksi etil asetat daun singkong mengandung senyawa rutin yang efektif menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini bertujuan mengetahui variasi konsentrasi kalsium klorida sebagai crosslinker terhadap transdermal patch yang dihasilkan dan mengetahui aktivitas antibakteri sediaan transdermal patch. Polimer yang digunakan pada penelitian ini adalah kitosan dan natrium alginat. Pembuatan transdermal patch dibuat dengan metode pencampuran (solvent casting) dalam 3 formula yakni FI, FII dan FIII dengan variasi konsentrasi kalsium klorida 0,5%, 0,75% dan 1%. Hasil formula terbaik didapatkan konsentrasi kalsium klorida 0,5% pada FI yang menghasilkan patch dengan permukaan halus, elastis dan transparan. Formula terbaik (FI) sediaan transdermal patch memiliki persen elongasi 80,116%, pH 6,72, keseragaman bobot 48,533 mg, kelembapan <4%, uji swelling 8.7471, ketebalan 0,117 mm, keseragaman kadar 100.008% ± 0.221. Hasil uji stabilitas menunjukkan bahwa sediaan transdermal patch baik dan stabil selama 6 siklus (p>0,05). Transdermal patch fraksi etil asetat daun singkong dengan konsentrasi kalsium klorida 0,5% memiliki karakterisasi dan stabilitas yang cukup baik. Transdermal patch fraksi etil asetat daun singkong menghasilkan diameter zona hambat sebesar15,86 ± 1,026 mm dengan kategori daya hambat kuat dan memiliki perbedaan signifikan terhadap kontrol positif (p<0,05).

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun singkong, Transdermal patch, Kalsium klorida. S.aureus
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Ratika Puteri
Date Deposited:	22 Mar 2024 01:53
Last Modified:	22 Mar 2024 01:53
URI:	http://repository.unsri.ac.id/id/eprint/141794

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