UJI AKTIVITAS ANALGETIK ANTIINFLAMASI FRAKSI ETIL ASETAT DAUN PACAR KAYU (Lawsonia inermis) PADA TIKUS PUTIH GALUR Wistar

ZISKA, MELIKA PUTRIANA and Muharni, Muharni and Amriani, Annisa (2024) UJI AKTIVITAS ANALGETIK ANTIINFLAMASI FRAKSI ETIL ASETAT DAUN PACAR KAYU (Lawsonia inermis) PADA TIKUS PUTIH GALUR Wistar. Undergraduate thesis, Sriwijaya University.

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Abstract

Lawsonia inermis is a medicinal herb that has been used to remedy sore throats, fevers, wounds and diarrhea. The ethanol extract of henna wood leaves is reported to be anti-inflammatory active. The efficacy of henna wood leaves as an anti-wound drug is related to its ability as an anti-inflammatory and analgetic. Compounds that provide anti-inflammatory activity are generally flavonoids and phenolic groups. Extraction of henna wood leaves is carried out using solvents with increased polarity (n-hexane and ethyl acetate) and then concentrated, resulting in viscous fractions of n-hexane and ethyl acetate. The ethyl acetate fraction is then tested for anti-inflammatory and analgetic activity. Anti-inflammatory parameters observed volume of swelling of the soles of the feet in carrageenan-induced test animals using pletismometer, analgetic activity using hot plate method with observation of latency time. The test was conducted with 5 treatment groups, the analgetic positive control group was given diclofenac sodium and anti-inflammatory aspirin, the negative group was given NaCMC solution, the test group was given ethyl acetate fractions doses of 200, 400, and 800 mg/kgBB. The results of the study of ethyl acetate fraction dose 800 mg/kgBB provided the highest anti-inflammatory activity compared to other doses with percent inhibition 68.91% higher than the positive control dose aspirin dose 100mg with percent inhibition 48.62%. Testing the analgetic activity of ethyl acetate fraction of henna wood leaves at a dose of 800 mg/kgBB also provided the highest analgetic activity compared to other doses with an analgetic percent of 17.03% which was almost the same as a positive control with an analgetic percent of 17.70%.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Lawsonia inermis, analgetik, antiinflamasi, fraksi etil asetat
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Melika Putriana Ziska
Date Deposited:	17 May 2024 03:45
Last Modified:	17 May 2024 03:45
URI:	http://repository.unsri.ac.id/id/eprint/144203

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