UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL DAUN KENCANA UNGU (Ruellia Tuberosa L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4

SEPTIAWAN, ARBAIM and Agustiarini, Vitri and Solihah, Indah (2024) UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL DAUN KENCANA UNGU (Ruellia Tuberosa L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4. Undergraduate thesis, Sriwijaya University.

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Abstract

The Purple golden leaves (Ruellia tuberosa L.) contain secondary metabolites in the form of flavonoid compounds which have antioxidant activity which can act as a hepatoprotector. This study aims to determine the hepatoprotective activity of ethanol extract of purple golden leaves (Ruellia tuberosa L.) in male Wistar white rats induced by CCl4 based on parameters measuring SGOT, SGPT and ALP levels, macroscopic and histopathological images of the rat liver. Purple golden leaves were extracted using the maceration method with 96% ethanol solvent. The research was carried out using 30 male white rats which were divided into 6 groups, namely normal control (Na CMC 0.5% p.o), positive control (silimarin 100 mg/KgBW), negative control (CCl4 1 mg/KgBW i.p), and test group for ethanol extract of purple golden leaves at doses of 50, 100, and 200 mg/KgBW. The results showed that administration of ethanol extract of purple golden leaves significantly (p<0.05) reduced SGOT, SGPT and ALP levels compared to the negative group. The effective dose 50 (ED50) value of the ethanol extract of purple golden leaves at SGOT, SGPT and ALP levels was 112.60 mg/KgBW, 121.63 mg/KgBW and 107.86 mg/KgBW. Based on the results of macroscopic observations and histopathology of rat livers, it shows that the treatment dose of 200 mg/KgBW is the most effective dose compared to the treatment doses of 50 and 100 mg/KgBW.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Hepatoprotektor, SGOT, SGPT, ALP, Histopatologi
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Arbaim Septiawan
Date Deposited: 26 May 2024 11:21
Last Modified: 26 May 2024 11:21
URI: http://repository.unsri.ac.id/id/eprint/145433

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