AKURASI D-DIMER SEBAGAI PREDIKTOR KEMATIAN PASIEN COVID-19 DI RSUD SITI FATIMAH PROVINSI SUMATERA SELATAN

SURANTI, DEWIE and Sitorus, Rico Januar and Andriyani Liberty, Iche (2024) AKURASI D-DIMER SEBAGAI PREDIKTOR KEMATIAN PASIEN COVID-19 DI RSUD SITI FATIMAH PROVINSI SUMATERA SELATAN. Masters thesis, Sriwijaya University.

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Abstract

Background: The COVID-19 pandemic, which has spread worldwide and resulted in fatalities, has had a significant impact. Globally, as of March 7, 2023, there have been 759,408,703 confirmed cases of COVID-19, including 6,866,434 deaths, reported to the WHO. Indonesia ranked first in the highest number of COVID-19 cases in ASEAN in 2021, with a total of 4,253,598 cases. According to the Indonesia Health Profile for 2021, the COVID-19 Case Fatality Rate (CFR) in Indonesia was 3.4%, with South Sumatra being the fifth-ranked province. The increase in D-dimer levels and poor laboratory test results serve as markers of worsening patient condition, which is also supported by age and comorbidities. The objective of this study was to determine the accuracy of D-dimer as a predictor of mortality in COVID-19 patients at RSUD Siti Fatimah. Method: This study employed a retrospective cohort design using secondary data from COVID-19 patients with medical records treated at RSUD Siti Fatimah, South Sumatra Province, from January to December 2021. The sampling technique involved total sampling, comprising 928 patients. Results: The majority of patients (83.94%) survived, and 59.16% had D-dimer levels below 500 ng/mL. The average D-dimer levels were higher in patients who died compared to those who survived (p-value<0.001), and there was a significant association between D-dimer levels and COVID-19 patient outcomes. The group of patients with D-dimer levels ≥ 500 ng/mL had a 3 times higher risk of death compared to the group of patients with D-dimer levels < 500 ng/mL, considering variables such as age, comorbid hypertension, diabetes mellitus, cardiovascular disease, tuberculosis, chronic obstructive pulmonary disease, symptoms, vaccination, oxygen saturation, leukocyte, and monocyte. The AUC (area under the curve) value was 0.969, with a sensitivity of 89% and a specificity of 96%. Conclusion: D-dimer serves as a predictor of mortality in COVID-19 patients at RSUD Siti Fatimah, South Sumatra Province.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Keywords: COVID-19, D-dimer, mortality
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	10-Faculty of Public Health > 13101-Public Health Science (S2)
Depositing User:	Dewie Suranti
Date Deposited:	18 Jul 2024 02:16
Last Modified:	18 Jul 2024 02:16
URI:	http://repository.unsri.ac.id/id/eprint/151484

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