FORMULASI DAN UJI ANTIOKSIDAN ORALLY DISSOLVING FILM EKSTRAK ETANOL BUNGA KECOMBRANG (Etlingera elatior) KOMBINASI PULLULAN DAN MALTODEKSTRIN DENGAN METODE FRAP

PASARIBU, BARTHOLOMEUS HASUDUNGAN and Miksusanti, Miksusanti and Wijaya, Dina Permata (2024) FORMULASI DAN UJI ANTIOKSIDAN ORALLY DISSOLVING FILM EKSTRAK ETANOL BUNGA KECOMBRANG (Etlingera elatior) KOMBINASI PULLULAN DAN MALTODEKSTRIN DENGAN METODE FRAP. Undergraduate thesis, Sriwijaya University.

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Abstract

Bunga kecombrang (Etlingera elatior) dikenal sebagai bunga khas Asia tenggara famili Zingiberaceae dengan warna merah menyala dan bau khas. Pemanfaatan sediaan orally dissolving film (ODF) dapat menetralisir rasa asam pada bunga kecombrang. Variasi konsentrasi ekstrak etanol bunga kecombrang 0,5%, 0,6%, 0,7%. Evalusi sediaan untuk menentukan formula terbaik meliputi organoleptis, ketebalan, bobot film, kelembaban, daya tahan lipat, persen elongasi, pH sediaan, waktu hancur. Formula terbaik dilakukan evaluasi keseragaman kadar dan uji antioksidan. Hasil skrining meliputi hasil positif mengandung senyawa fitokimia flavonoid, tanin, saponin, terpenoid. Hasil kadar flavonoid total mengandung 7,700%. Evaluasi formula F2 didapatkan sebagai formula terbaik dengan spesifikasi ketebalan 0,06 mm, bobot film 3,71% CV, kelembaban film 1,09%, daya tahan lipat 522 lipatan, persen elongasi 66,545%, pH 4,38, waktu hancur 15,07 detik. Hasil keseragaman kadar formula F2 didapatkan % recovery 54,32. Hasil pengujian didapatkan IC50 asam askorbat 57,99 ppm; kuat, ekstrak etanol bunga kecombrang 8861ppm; sangat lemah, Formula terbaik F2 2420,52 ppm; sangat lemah, Formula F3 pembanding 1729,27ppm; sangat lemah, plasebo 21224,47 ppm; sangat lemah

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ekstrak etanol bunga kecombrang (Etlingera elatior), Orally dissolving film pullulan, antioksidan, FRAP
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Bartholomeus Hasudungan Pasaribu
Date Deposited:	25 Nov 2024 06:53
Last Modified:	25 Nov 2024 06:53
URI:	http://repository.unsri.ac.id/id/eprint/159830

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