UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL BUNGA BUGENVIL UNGU (Bougainvillea spectabilis Willd.) PADA TIKUS PUTIH JANTAN GALUR WISTAR

DAMAYANTI, RIRI and Muharni, Muharni and Amriani, Annisa (2025) UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL BUNGA BUGENVIL UNGU (Bougainvillea spectabilis Willd.) PADA TIKUS PUTIH JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

Preview	Image RAMA_48201_08061282126048_cover.jpg - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (347kB) | Preview
	Text RAMA_48201_08061282126048.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061282126048_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061282126048_0004036903_0029128405_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (631kB)
	Text RAMA_48201_08061282126048_0004036903_0029128405_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (358kB) | Request a copy
	Text RAMA_48201_08061282126048_0004036903_0029128405_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (275kB) | Request a copy
	Text RAMA_48201_08061282126048_0004036903_0029128405_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (306kB) | Request a copy
	Text RAMA_48201_08061282126048_0004036903_0029128405_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (143kB) | Request a copy
	Text RAMA_48201_08061282126048_0004036903_0029128405_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (199kB) | Request a copy
	Text RAMA_48201_08061282126048_0004036903_0029128405_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

flavonoid compounds and has the potential as an antihyperuricemia. This study aims to evaluate the antihyperuricemia activity of ethanol extract of B. spectabilis in male white rats of the Wistar strain. Extraction was carried out by the maceration method using 96% ethanol. The extract was characterized and tested the antihyperuricemia activity used 35 rats male were divided into 7 groups: normal group, positive control (allopurinol), negative control (0,5% Na-CMC), and the treatment group of ethanol extract of B. spectabilis with doses of 100, 200, 400, and 800 mg/kg BW. Before testing, the rats were made in a hyperuricemia condition by giving 25 mL/kg BW chicken liver juice and 2 g/kg BW melinjo seeds. Uric acid levels were measured on days 0, 15, 20, 25, and 30 using the spectrophotometric method. The extract showed results that met the requirements. The extract showed antihyperuricemia activity and the highest activity was shown by the 800 mg/kg BW dose group. Statistical analysis showed that there was no significant difference between the 800 mg/kg BW dose group and the allopurinol positive control (p>0,05), but there was significant difference with other treatment groups (p<0,05), and there was no significant difference between the 100, 200, and 400 mg/kg BW dose treatment groups (p>0,05). The Effective Dose 50 (ED50) value was 394,39 mg/kg BW. These results indicate that the ethanol extract of B. spectabilis has the potential for antihyperuricemia activity. Keywords: Antihyperuricemia, Bougainvillea spectabilis, Effective Dose, Ethanol Extract

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antihiperurisemia, Bougainvillea spectabilis, Dosis Efektif, Ekstrak Etanol
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Riri Damayanti
Date Deposited:	06 Mar 2025 05:34
Last Modified:	06 Mar 2025 05:34
URI:	http://repository.unsri.ac.id/id/eprint/167971

Actions (login required)

View Item