POTENSI ANTIMALARIA METABOLIT SEKUNDER Lansium domesticum TERHADAP ENZIM Plasmodium falsiparum Lactate dehydrogenase (PfLDH) SECARA IN SILICO

NIRWANA, RAHMA JULIA and Hanum, Laila (2025) POTENSI ANTIMALARIA METABOLIT SEKUNDER Lansium domesticum TERHADAP ENZIM Plasmodium falsiparum Lactate dehydrogenase (PfLDH) SECARA IN SILICO. Undergraduate thesis, Sriwijaya University.

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Abstract

Malaria is one of the infectious and deadly diseases in the world. If not treated immediately, malaria will develop into more dangerous complications such as severe anemia, organ damage, and death. Plasmodium falsiparum is a serious infection with a high mortality rate and is a type of cerebral malaria. Plasmodium falsiparum lactate dehydrogenase (PfLDH) enzyme is used as one of the potential molecular target enzymes for antimalarials because Plasmodium falsiparum depends on glycolysis to produce energy. Some malaria drugs that have been found such as chloroquine, artemisinin, and the combination of artemisunate with mefloquine have difficulty in treating malaria cases. The native Indonesian plant Lansium domesticum has the potential to be a natural medicinal material for antimalarial, the content of the compounds contained can be antimalarial. antimalarial drug development is carried out with an In-silico approach using certain computational parameters and algorithms to model the interaction between test compounds and target enzymes. In-silico studies include prediction of biological activity of Lansium domesticum compounds as antimalarials, prediction of physicochemical properties, prediction of pharmacokinetic properties, prediction of toxicity properties and prediction of molecular interactions between test compounds and PfLDH target enzyme using molecular docking method. The results obtained, 47 Lansium domesticum compounds have biological activity as antimalarials. Based on physicochemical, pharmacokinetic, and toxicity predictions of 47 compounds, 4 test compounds were obtained, namely is-3-Hexen-1-ol, Aromadendrene, Isoledene, dan Hexadecanoic acid from Lansium domesticum which are safe candidates for antimalarial drugs. In the docking process, the test compounds and the PfLDH enzyme produce binding affinity values and molecular interactions. Hexadecanoic acid test compound produces 3 amino acid bonds namely GLY29, THR97, and HIS195 which are the same as the active side compared to control and natural ligands. Keywords : Antimalarial, Lansium domesticum, PfLDH, Molecular docking, In-silico

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antimalaria, Lansium domesticum, PfLDH, Molecular docking, In-silico
Subjects:	Q Science > Q Science (General) > Q1-295 General Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) > R858-859.7 Computer applications to medicine. Medical informatics R Medicine > RL Dermatology > RL760-785 Diseases due to parasites
Divisions:	08-Faculty of Mathematics and Natural Science > 46201-Biology (S1)
Depositing User:	Rahma Julia Nirwana
Date Deposited:	24 Mar 2025 03:07
Last Modified:	24 Mar 2025 03:07
URI:	http://repository.unsri.ac.id/id/eprint/169947

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