MURTADHO, MASAGUS AHMAD RIFQI and Zulkifli, Zulkifli and Haloho, Agustina Br. and Liberty, Iche Andriyani (2025) HUBUNGAN KELEBIHAN CAIRAN DENGAN ACUTE KIDNEY INJURY PASIEN SEPSIS DI UNIT PERAWATAN INTENSIF RS MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.
![[thumbnail of RAMA_11706_04102782125006_cover.jpg]](http://repository.unsri.ac.id/171114/19/RAMA_11706_04102782125006_cover.jpg)  Preview |
Image
RAMA_11706_04102782125006_cover.jpg - Cover Image Available under License Creative Commons Public Domain Dedication. Download (369kB) | Preview |
![[thumbnail of RAMA_11706_04102782125006.pdf]](http://repository.unsri.ac.id/style/images/fileicons/text.png) |
Text
RAMA_11706_04102782125006.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) |
|
Text
RAMA_11706_04102782125006_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (17MB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (844kB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (240kB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (292kB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (13kB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (111kB) |
|
Text
RAMA_11706_04102782125006_8898820016_8819520016_0007029001_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) |
Abstract
Background: Fluid management is one of the main pillars in the management of sepsis and sepsis shock, where proper fluid management can avoid the most frequent complication of sepsis, namely acute kidney injury. Methods: A retrospective cohort study was conducted on 295 adult sepsis patients admitted to the ICU between January 2022 and December 2024. Fluid overload was categorized using the cumulative fluid balance ROC curve. Statistical analysis included Chi-Square, T-test, and multivariate logistic regression to analyze the association of fluid overload with AKI. Results: Fluid overload was significantly associated with AKI (p<0.001) with an RR value of 12.878 (95% CI = 6.952-23.857). The ROC curve showed excellent predictive value of cumulative fluid balance on AKI. The cut off point value of cumulative fluid balance was >-77 ml. Multivariate analysis found fluid overload as an independent risk factor. Discussion: The results of this study support evidence from previous studies that fluid overload is significantly associated with AKI. The provision of fluid therapy is a management that must be done wisely and carefully. Fluid administration in critical patients consists of four stages known as the ROSE concept, namely resuscitation, optimization, stabilization, and evacuation. The evacuation phase includes the process of deresuscitation which has an important role in patients who experience fluid overload. Conclusion: Fluid overload is an excellent predictor of AKI. Individualized and restrictive fluid strategies have been shown to reduce the risk of AKI in sepsis patients in the ICU. Keywords: Sepsis, Fluid Overload, Acute Kidney Injury
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R726.5-726.8 Medicine and disease in relation to psychology. Terminal care. Dying |
| Divisions: | 04-Faculty of Medicine > 11706-Anestesiology and Reanimation (Sp |
| Depositing User: | Masagus Ahmad Rifqi Murtadho |
| Date Deposited: | 08 May 2025 02:21 |
| Last Modified: | 08 May 2025 02:21 |
| URI: | http://repository.unsri.ac.id/id/eprint/171114 |
Actions (login required)
 |
View Item |