NADILLA, PUTRI and Hanum, Laila (2025) SKRINING SENYAWA METABOLIT SEKUNDER Lansium domesticum Corr. YANG BERPOTENSI SEBAGAI ANTIDIABETIK TERHADAP ENZIM α-glukosidase SECARA IN SILICO. Undergraduate thesis, Sriwijaya University.
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Abstract
Diabetes mellitus is a disease that experiences an increase in the number of sufferers every year with treatment from synthetic ingredients that can cause harmful side effects to the body. Therefore, the discovery of a natural source of materials from Lansium domesticum Corr. that can inhibit the work of the enzyme α-glucosidase has emerged. Inhibition of the action of diabetes enzymes is one of the potential targets in controlling sugar levels. The enzyme α-glucosidase can be done by inhibiting the active side of the enzyme so that it can slow down the digestion and absorption of carbohydrates. Molecular docking can predict the interaction between compounds from Lansium domesticum Corr. and the target protein enzyme α-glucosidase in silico. Therefore, it is important to search for metabolite compounds from Lansium domesticum Corr. that have the potential to be antidiabetic in inhibiting the enzyme α-glucosidase by producing the lowest binding affinity value and a group of compounds from ligands that can bind to receptors are carried out in silico which can be utilized by having physicochemical, pharmacokinetic biological activity and safe from toxicity. It was carried out by an experimental method in silico to obtain the binding affinity interaction between ligands from Lansium domesticum Corr. compounds and α-glucosidase enzyme receptors safely. The resulting 38 secondary metabolite compounds of Lansium domesticum Corr. have biological activity as an antidiabetic by inhibiting the action of the enzyme α-glucosidase. Based on physicochemical, pharmacokinetic, and toxicity predictions from 38 compounds, 4 Lansium domesticum Corr. test compounds were obtained that were safe to be antidiabetic candidates, namely Catechin, Aphanamol II, Spathulenol and Isogemacrene D were able to inhibit the active side of the enzyme α-glucosidase in silico. Keyword: Antidiabetic, Lansium domesticum Corr., α-glucosidase, in silico, Molecular docking.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | Antidiabetik, Lansium domesticum Corr., α-glukosidase, in silico, Molecular docking |
| Subjects: | Q Science > Q Science (General) > Q1-295 General Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) > R858-859.7 Computer applications to medicine. Medical informatics R Medicine > RC Internal medicine > RC627.5-632 Metabolic diseases R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 46201-Biology (S1) |
| Depositing User: | Putri Nadilla |
| Date Deposited: | 02 May 2025 02:43 |
| Last Modified: | 02 May 2025 02:43 |
| URI: | http://repository.unsri.ac.id/id/eprint/171233 |
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