ISOLASI SENYAWA STEROID DARI DAUN TUMBUHAN DAUN WUNGU (Graptophyllum pictum (L.) Griff) dan UJI AKTIVITAS ANALGETIKA TERHADAP MENCIT JANTAN (Mus musculus)

LESTARI, WINDA OKTA and Muharni, Muharni and Herlina, Herlina (2015) ISOLASI SENYAWA STEROID DARI DAUN TUMBUHAN DAUN WUNGU (Graptophyllum pictum (L.) Griff) dan UJI AKTIVITAS ANALGETIKA TERHADAP MENCIT JANTAN (Mus musculus). Undergraduate thesis, Sriwijaya University.

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Abstract

Isolation of steroid compound from the leaves of daun wungu (Graptophyllum pictum (L.) Griff) in n-hexane fraction has been done. The extraction was carried out through maceration following with separation and purification by chromatography technique. The Isolated compound was a white needle crystal. The structure of this compound was determined using 1H-NMR and 13C-NMR. The analgesic activity of the isolated compound was tested on male mice by writhing test method with intraperitoneal (i.p) injection of 1% acetic acid as the pain-inducer. The spectral data analysis were suggested that the isolated compound is a steroid β-sitosterol. The isolated compound showed that pain-inhibition activity was 51.2 % for 1 mg/20 g BB dose, 64.7 % for 2 mg/20 g BB dose and 72.3 % for 4 mg/20 g BB dose. The analgesic activity of the isolated compound is lower than the aspirin.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun Wungu leaves, Graptophyllum pictum (L.) Griff, Steroid,β-sitosterol, analgesic activity.
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry Q Science > QD Chemistry > QD241-441 Organic chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	20 Nov 2019 04:59
Last Modified:	20 Nov 2019 05:35
URI:	http://repository.unsri.ac.id/id/eprint/17295

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