UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN SIRIH HIJAU (Piper betle.L) TERHADAP MENCIT JANTAN (Mus musculus)

AZIZAH, AZIZAH and Lamin, Syafrina and Starlista, Viva (2025) UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN SIRIH HIJAU (Piper betle.L) TERHADAP MENCIT JANTAN (Mus musculus). Undergraduate thesis, Sriwijaya University.

Preview	Image RAMA_48201_08061282126046_Cover.jpg - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (316kB) | Preview
	Text RAMA_48201_08061282126046.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061282126046_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_48201_08061282126046_0011116214_0027049502_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB)
	Text RAMA_48201_08061282126046_0011116214_0027049502_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (500kB) | Request a copy
	Text RAMA_48201_08061282126046_0011116214_0027049502_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (316kB) | Request a copy
	Text RAMA_48201_08061282126046_0011116214_0027049502_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (332kB) | Request a copy
	Text RAMA_48201_08061282126046_0011116214_0027049502_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (280kB) | Request a copy
	Text RAMA_48201_08061282126046_0011116214_0027049502_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (225kB) | Request a copy
	Text RAMA_48201_08061282126046_0011116214_0027049502_07_lamp (2.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Green betel leaves (Piper betle L.) contain flavonoids, tannins, and saponins that have the potential as natural hemostatic agents. This study aims to determine the effect of ethanol extract of green betel leaves on bleeding time and blood clotting time in male mice (Mus musculus), and to determine its effective dose. This study was divided into five treatment groups, namely negative control (1% NaCMC), positive control (500 mg/kgBW tranexamic acid), and ethanol extract of green betel leaves with doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW. Bleeding time was observed using the Duke method and blood clotting time using the slide method. The results showed that green betel leaf extract was able to accelerate hemostasis time significantly (p <0.05), with a dose of 200 mg/kgBW showing the most optimal effectiveness and approaching the results shown by the positive control. The hemostasis mechanism of this extract is thought to be related to platelet activation by flavonoids, as well as the role of tannins and saponins in vasoconstriction and blood protein binding. Based on these results, the ethanol extract of green betel leaves has the potential as a natural hemostatic agent.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	bleeding time, clotting time, Daun sirih hijau, Hemostasis
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Azizah Azizah
Date Deposited:	07 Jul 2025 03:43
Last Modified:	07 Jul 2025 03:43
URI:	http://repository.unsri.ac.id/id/eprint/176954

Actions (login required)

View Item