KARAKTERISASI LIPOSOM PHOTOSENSITIZER PEMBAWA EKSTRAK KASAR NANAS (Ananas comosus (L.) Merr) SEBAGAI AGEN TROMBOLITIK

MARRISCA, RUMIYATI DWI NINDI and Fithri, Najma Annuria (2025) KARAKTERISASI LIPOSOM PHOTOSENSITIZER PEMBAWA EKSTRAK KASAR NANAS (Ananas comosus (L.) Merr) SEBAGAI AGEN TROMBOLITIK. Undergraduate thesis, Sriwijaya University.

	Image RAMA_48201_08061282126035_cover.jpg - Cover Image Available under License Creative Commons Public Domain Dedication. Download (962kB)
	Text RAMA_48201_08061282126035.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_48201_08061282126035_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_48201_08061282126035_0025038802_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (826kB)
	Text RAMA_48201_08061282126035_0025038802_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061282126035_0025038802_03.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (335kB) | Request a copy
	Text RAMA_48201_08061282126035_0025038802_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061282126035_0025038802_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (165kB) | Request a copy
	Text RAMA_48201_08061282126035_0025038802_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (350kB) | Request a copy
	Text RAMA_48201_08061282126035_0025038802_07_lamp.pdf - Accepted Version Restricted to Repository staff only Download (1MB) | Request a copy

Abstract

Thrombosis is a condition that occurs due to an imbalance in the hemostasis system characterized by the formation of a blood clot (thrombus) in the blood vessel wall so that it can cause ischemic stroke disease. The anti-thrombotic drugs commonly used are thrombolytics. These drugs contain fibrinolytic enzymes such as protease enzymes. Pineapple (Ananas comosus (L.) Merr) is known to have an anti-thrombotic pharmacological effect because it contains proteolytic enzymes, namely bromelain enzymes. Liposomes are used as a drug delivery system (DDS) because of their ability to protect enzymes from degradation. This study aims to determine the type of phospholipid that can produce the best thrombolytic activity. The types of phospholipids used for the manufacture of these liposomes are phosphatidylcholine from soy lecithin and Lipoid S100®, both of which have different phosphatidylcholine purities, namely 65% and 94%. Based on the results of the thrombolytic activity test, the liposome formula using Lipoid S100® (Lipoid, Germany) had the best results with a liposome size of 599.2 nm; PDI of 0.516; zeta potential of -13.4 mV and spherical liposomes. The characterization results for F1 and F3 showed good %EE, photothermal efficiency of 49.75% and 25.53%, and thrombolytic activity values with 450 nm laser testing of 27.74% and 25.54%. The results of this study show good thrombolytic results, but further research is needed to improve particle dispersion and increase phycocyanin stability.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ekstrak nanas (Ananas comosus (L.) Merr), liposom photosensitizer, fikosianin, sodium fluorescein, trombolitik
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Rumiyati Dwi Nindi Marrisca
Date Deposited:	18 Sep 2025 07:52
Last Modified:	18 Sep 2025 07:52
URI:	http://repository.unsri.ac.id/id/eprint/184246

Actions (login required)

View Item