FORMULASI DAN UJI ANTIOKSIDAN DENGAN METODE DPPH SEDIAAN GEL EKSTRAK ETANOL DAUN KOPI ROBUSTA (Coffea canephora) BERBASIS HPMC 60SH

ASTRYANI, REGINA and Herlina, Herlina and Wijaya, Dina Permata (2019) FORMULASI DAN UJI ANTIOKSIDAN DENGAN METODE DPPH SEDIAAN GEL EKSTRAK ETANOL DAUN KOPI ROBUSTA (Coffea canephora) BERBASIS HPMC 60SH. Undergraduate thesis, Sriwijaya University.

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Abstract

Antioxidants is a substance needed body to scavange free radical and prevent damage caused by free radical to normal cells, proteins and fat. Robusta coffe leaves (Coffea canephora) consisted of alkaloids, flavonoid, phenolic, tannin, quinon, steroid/ triterpenoid, and cumarine which have potential as antioxidant.To increase the effectivity of coffe leaves extract as an antioxidant on skin, the extract is being formulated with gel with active ingredient robusta coffe leaves ethanol extract. HPMC 60SH as gelling agent is used eith variations of concentration 6%, 4%, 2%. Gel in the evaluation included organoleptic, homogenity, spreadability, sticking power, washability, pH, viscosity and stability. The influence of the concentration of HPMC 60SH is directed on the decrease of gel’s spreadability, washability, and pH, but also increase of sticking power and viscosity. Total flavonoid concentration at ethanol extract, formula 1, formula 2 and formula 3 respectively is 111,606 mg/g ; 30,173 mg/g ; 31,903 mg/g ; 33,823 mg/g. Three of the formulas is tested the antioxidant activity using DPPH ( 1,1 dyphenyl-2-pycrihydrazyl) with vitamin C as the control . IC50 value of vitamin C, formula 1, formula 2 and formula 3 respectively are 11,14 µg/ml ; 98,812 µg/ml ; 78,65 µg/ml ; 65,58 µg/ml. There is big significance (p<0,05) between vitamin C 5 ppm and all the tested sample. Keyword(s) : gel, robusta coffee leaves, HPMC 60SH, antioxidant, DPPH.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	gel, robusta coffee leaves, HPMC 60SH, antioxidant, DPPH.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 568 not found.
Date Deposited:	03 Aug 2019 00:32
Last Modified:	03 Aug 2019 00:32
URI:	http://repository.unsri.ac.id/id/eprint/2004

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