Fitrya, Fitrya (2020) Immunomodulatory effect of Parkia speciosa Hassk. pods extract on rat induced by Salmonella typhimurium. Journal of Pharmacy & Pharmacognosy Research, 8 (5). pp. 457-465. ISSN 0719-4250
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Abstract
Context: Parkia speciosa, which has phenolic compounds and pharmacology activities, is a plant having potential immunomodulatory agents from the extract of its pod. Aims: To evaluate the potential of P. speciosa as an immunomodulatory agent tested on albino rats induced by the bacteria Salmonella typhimurium leading to typhoid fever. Methods: The animals were divided into six groups: normal non-infected group, negative control group, positive control, and three test groups with doses of 200, 400 and 800 mg/kg BW. The test groups were treated by the extract for 12 days. The control and test groups were induced with the S. typhimurium on the 8th day. On day 12th, CD4+, total leukocytes, differential cell count, and histology of the spleen organ were evaluated. Statistical analysis was performed by using one-way ANOVA followed post hoc LSD test (α 0.05). Results: The result showed that the ethanol extract of P. speciosa pod could increase the number of CD4+. The extract to 200 and 400 mg/kg BW doses increased in the parameters of leukocyte, neutrophil, lymphocyte and monocyte with insignificant differences compared to that of the positive control group (p>0.05). However, there were significant differences between the two first parameters between the test group with 800 mg/kg BW doses compared to the positive control group. Moreover, more necroses in the spleen were observed from histological analysis on 800 mg/kg BW doses than 400 mg/kg BW. Conclusions: In general, P. speciosa ethanolic extract can increase the immune system based on the CD4+ count, leukocyte, monocyte, and neutrophil, and causes normal necroses in low doses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Parkia speciosa; immunomodulator; Salmonella typhimurium; typhoid fever |
| Subjects: | #3 Repository of Lecturer Academic Credit Systems (TPAK) > Hak Atas Kekayaan Intelektual (HAKI)-PATENT |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1) |
| Depositing User: | M.Si, Apt. Fitrya Fitrya |
| Date Deposited: | 05 Jan 2021 07:13 |
| Last Modified: | 05 Jan 2021 07:13 |
| URI: | http://repository.unsri.ac.id/id/eprint/38985 |
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