UJI AKTIVITAS ANTHELMINTIK PERASAN DAN EKSTRAK ETANOL DAUN ANDONG MERAH (Cordyline fruticosa (L.) A. Chev.) TERHADAP CACING Ascaris suum, Goeze

MAIDILAH, MAIDILAH and Herlina, Herlina and Solihah, Indah (2018) UJI AKTIVITAS ANTHELMINTIK PERASAN DAN EKSTRAK ETANOL DAUN ANDONG MERAH (Cordyline fruticosa (L.) A. Chev.) TERHADAP CACING Ascaris suum, Goeze. Undergraduate thesis, Sriwijaya University.

Preview	Text RAMA_48201_08061281419094_0003077102_0008038802_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview
	Text RAMA_48201_08061281419094_0003077102_0008038802_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (454kB) | Request a copy
	Text RAMA_48201_08061281419094_0003077102_0008038802_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (334kB) | Request a copy
	Text RAMA_48201_08061281419094_0003077102_0008038802_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (605kB) | Request a copy
	Text RAMA_48201_08061281419094_0003077102_0008038802_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (92kB) | Request a copy
	Text RAMA_48201_08061281419094_0003077102_0008038802_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (273kB) | Request a copy
	Text RAMA_48201_08061281419094_0003077102_0008038802_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Worm diseases is common in Indonesia with 31.8% prevalence based on Ministry of Health data of 2012. Pirantel pamoat which is a drug of choice for ascariasis has many side effects and has caused resistance in some cases. Cordyline fruticosa (L.) A. Chev. leaves contains flavonoid compounds, tannins, saponins, and phenolic compounds that are efficacious as anthelmintic. This research was conducted to find out the anthelmintic potency of the juice and the ethanol extract of C. fruticosa leaves against Ascaris suum, Goeze worm. C. fruticosa leaves juice was obtained by addition of aquades and smoothing, while ethanol extract was obtained by maceration using 96% ethanol. Tests were performed on 16 treatment groups consisting of negative control group (NaCl 0.9%), juice (10, 20, 30, 40, and 50%), ethanol extract (10, 20, 30, 40, and 50%), and the positive control group (pirantel pamoat 0.1, 0.2, 0.3, 0.4, and 0.5%), in an incubator at 37 ° C with a time limit 45 hours. The C. fruticosa ethanol extract has a specific characteristic of thick, dark brown, aroma like tea, water soluble extract 44.6 ± 0.264%, ethanol soluble extract 81.566 ± 0.321%, and chemical content of flavonoid, phenolic, saponin, steroids, and tannins, and having non-specific characteristics with percent water content, shrinkage dried, and density respectively of 7.6 ± 0.1%, 7.681 ± 0.067%%, and 1.013 ± 0.001 g/mL. The test results show that the juice and ethanol extract have antelmintic potency to Ascaris suum, Goeze in vitro. The LC50 and LT50 juice is 23.957% and 8.125 hours, while ethanol extract is 19.426% and 5.334 hours, where its anthelmintic potency is lower than pirantel pamoat which has LC50 0.224% and LT50 2.708 hours.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	anthelmintic, Ascaris suum Goeze, Cordyline fruticosa (L.) A. Chev., pirantel pamoat
Subjects:	R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	23 Aug 2019 09:16
Last Modified:	23 Aug 2019 09:16
URI:	http://repository.unsri.ac.id/id/eprint/4842

Actions (login required)

View Item