AKTIVITAS ANTIDIABETES EKSTRAK ETIL ASETAT DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI DIET TINGGI LEMAK DAN FRUKTOSA

TASNIAR, ADE IRA and Herlina, Herlina and Solihah, Indah (2021) AKTIVITAS ANTIDIABETES EKSTRAK ETIL ASETAT DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI DIET TINGGI LEMAK DAN FRUKTOSA. Undergraduate thesis, Sriwijaya University.

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Abstract

Salam leaves (Syzygium polyanthum Wight.) empirically have been used as traditional antidiabetic drugs. Male Wistar albino rats are used as animal models which divide into 6 group, normal group, negative control group (Na CMC 0,5%), positive control group (Metformin 150 mg/kgBB), and 3 test group (ethyl acetate extract of salam leaves 250, 500, and 1000 mg/kgBB). The result of characterization of moisture content 7.07%, loss on drying content 7.62%, ash content 11.02%, and insoluble ash content in acid 6,41%. Phytochemical test ekstrak showed the content of flavonoid, phenolic, and alkaloid. The result of AUC30-45 and percentage of decreasing blood glucose level for positive control group are 1900.30 and 70.83%, and 3 test group (250 mg/kgBB, 500 mg/kgBB, dan 1000 mg/kgBB) are 1940.32 and 62.13% ; 1909.36 and 68.88%; 1819 and 88.21%. This point indicate that ethyl acetat extract of salam leaves has an antidiabetic activity and there is no significant difference compared with metformin (p>0,05). According to the relation between percentage of blood glucose level with dose, value of ED50 of ethyl acetate extract of salam leaves is 213.46 mg/kgBB. Histopathological results of the pancreas showed an improvement in the group that treated with salam leaves extract at doses of 250, 500 and 1000mg/kgBB comparing other groups. Which is dose of 1000mg/kgBB gives the best impact Keyword(s): ethyl acetat extract, salam leaves, antidiabetic, high fat and fructose diet, the pancreas histopathology

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	ekstrak etil asetat, daun salam, antidiabetes, diet tinggi lemak dan fruktosa, Histopatologi pankreas
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Ade Ira Tasniar
Date Deposited:	10 Aug 2021 06:40
Last Modified:	10 Aug 2021 06:40
URI:	http://repository.unsri.ac.id/id/eprint/51924

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