UJI AKTIVITAS DIURETIK FRAKSI ETIL ASETAT DAUN SUKUN (Artocarpus altilis) PADA TIKUS PUTIH JANTAN WISTAR

LESTARI, SHERLY VIOLETA and Fitrya, Fitrya and Amriani, Annisa (2022) UJI AKTIVITAS DIURETIK FRAKSI ETIL ASETAT DAUN SUKUN (Artocarpus altilis) PADA TIKUS PUTIH JANTAN WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Ethyl acetate fraction of breadfruit leaves (Artocarpus altilis) contains many secondary metabolites, one of which is the phenolic compounds. Phenolic compounds in ethyl acetate fraction of breadfruit leaves are suspected as diuretics. This study aims to determine the effect from different doses of the ethyl acetate fraction of breadfruit leaves as a diuretic. Diuretic activity test used 30 male white rats which were divided into 6 treatment groups. The normal group was given distilled water, the negative group was given 4.5% NaCl, the positive group was given furosemide 20 mg/200gBB, and groups I, II, and III were given ethyl acetate fraction of breadfruit leaves with a dose respectively 25 mg/200gBW, 50 mg/200gBW, and 100mg/200gBW. Parameters observed included increase in urine volume and levels of Na+, K+, and Cl- ions. The result showed that the ethyl acetate fraction of breadfruit leaves dose 100 mg/200gBW can increase urine volume significantly different from group of untreated animals and given furosemid (p<0.05) with the percentage of diuretic potency is 168.05%. Statistical analysis also showed that were significantly differences of the levels of Na+, K+, and Cl- ions each group (p<0.05). The effective dose (ED50) obtained from ethyl acetate fraction of breadfruit leaves was 25.93 mg/200gBW. Keywords : Artocarpus altilis, Fenolic, Diuretic, Urine, Na+; K+; and Cl- ions levels Fraksi etil asetat daun sukun (Artocarpus altilis) mengandung banyak metabolit sekunder, salah satunya golongan fenolik, Senyawa fenolik pada fraksi etil asetat daun sukun diduga berpotensi sebagai diuretik. Penelitian ini bertujuan mengetahui pengaruh perbedaan dosis fraksi etil asetat daun sukun sebagai diuretik. Uji aktivitas diuretik ini meggunakan 30 ekor tikus yang dibagi menjadi 6 kelompok. Kelompok normal diberi akuades, kelompok negatif diberi NaCl 4,5%, kelompok positif diberi furosemide 20 mg/200gBB, dan kelompok uji I, II, dan III diberi fraksi etil asetat daun sukun dengan dosis masing-masing 25 mg/200gBB, 50 mg/200gBB, dan 100 mg/200gBB. Parameter yang diamati berupa penigkatan volume urin dan kadar ion Na+, K+, dan Cl-. Hasil analisis volume urine menunjukkan bahwa pemberian fraksi etil asetat daun sukun dosis 100 mg/200gBB mampu meningkatkan volume urine yang nyata berbeda dengan kelompok kontrol negatif dan positif (p<0.05) dengan persen potensi diuretik yang paling tinggi sebesar 168.05%. Analisis statistik juga menunjukkan bahwa terdapat perbedaan yang bermakna terhadap kadar ion Na+, K+, dan Cl- pada setiap kelompok (p<0.05). Dosis efektif (ED50) yang diperoleh dari fraksi etil asetat daun sukun sebesar 25,93 mg/200gBB. Kata Kunci : Artocarpus altilis, Fenolik, Diuretik, Urine, Kadar Ion Na+; K+: dan Cl-

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Farmakologi Bahan Alam
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Sherly Violeta Lestari
Date Deposited:	02 Jun 2022 02:59
Last Modified:	02 Jun 2022 02:59
URI:	http://repository.unsri.ac.id/id/eprint/71197

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